{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:40:17Z","timestamp":1760985617414,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["692298"],"award-info":[{"award-number":["692298"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Associations between immunoglobulin (IG) receptors with distinctive immunogenetic features and particular gene mutations are a recurring theme in mature B\u2010cell lymphomas. Relevant observations have been made in chronic lymphocytic leukemia (CLL), where gene mutations are distributed asymmetrically in cases bearing or not somatic hypermutations within the clonotypic immunoglobulin heavy chain variable region (IGHV) genes (e.g. <jats:italic>TP53<\/jats:italic> mutations predominate in IG\u2010unmutated CLL, whereas the opposite is seen for <jats:italic>MYD88<\/jats:italic> mutations, enriched in IG\u2010mutated CLL) and in subsets of cases with stereotyped IG (enrichment for <jats:italic>SF3B1<\/jats:italic> mutations in CLL subset #2). Moreover, similar findings have been reported in splenic marginal\u2010zone lymphoma, where <jats:italic>KLF2<\/jats:italic> mutations are biased to cases expressing IGHV1\u20102*04 IG receptors, and in hairy cell leukemia, where IGHV4\u201034\u2010expressing cases display a low frequency of <jats:italic>BRAF<\/jats:italic> mutations but a high frequency of <jats:italic>MAP2K1<\/jats:italic> mutations. The list is now growing with the report of increased frequency of inactivating mutations in the <jats:italic>TNFAIP3<\/jats:italic> gene in MALT lymphomas expressing IG receptors encoded by the IGHV4\u201034 gene, particularly of the ocular adnexa. Considering that <jats:italic>TNFAIP3<\/jats:italic> encodes a negative regulator of NF\u2010\u03baB, this finding further highlights the importance of NF\u2010\u03baB pathway activation in the natural history of MALT lymphomas. Altogether, these findings allude to selection of genomic aberrations in lymphoma cases with distinctive immune signaling profiles linked to the expression of particular IG receptors. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4982","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T11:42:46Z","timestamp":1505130166000},"page":"403-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A gene is known by the company it keeps: enrichment of <i>TNFAIP3<\/i> gene aberrations in MALT lymphomas expressing IGHV4\u201034 antigen receptors"],"prefix":"10.1002","volume":"243","author":[{"given":"Andreas","family":"Agathangelidis","sequence":"first","affiliation":[{"name":"Institute of Applied Biosciences, CERTH The Centre for Research and Technology Hellas  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliki","family":"Xochelli","sequence":"additional","affiliation":[{"name":"Institute of Applied Biosciences, CERTH The Centre for Research and Technology Hellas  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-640X","authenticated-orcid":false,"given":"Kostas","family":"Stamatopoulos","sequence":"additional","affiliation":[{"name":"Institute of Applied Biosciences, CERTH The Centre for Research and Technology Hellas  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_4_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.322"},{"key":"e_1_2_4_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.3"},{"key":"e_1_2_4_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4933"},{"key":"e_1_2_4_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.11.005"},{"key":"e_1_2_4_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2016.07.003"},{"key":"e_1_2_4_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0398-6_3"},{"key":"e_1_2_4_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.1479.1479"},{"key":"e_1_2_4_2_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029114"},{"key":"e_1_2_4_2_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200112462"},{"key":"e_1_2_4_2_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0630"},{"key":"e_1_2_4_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.196"},{"key":"e_1_2_4_2_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.109777"},{"key":"e_1_2_4_2_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.134510"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:01:13Z","timestamp":1760954473000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/path.4982"],"URL":"https:\/\/doi.org\/10.1002\/path.4982","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}