{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:31:47Z","timestamp":1761744707580,"version":"build-2065373602"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61327902\u20104","81230062","81602197","81402080"],"award-info":[{"award-number":["61327902\u20104","81230062","81602197","81402080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently identified as the second receptor for anthrax toxin (ANTXR2). Although tumor\u2010associated functions of CMG2 have also been reported, the clinical significance and functional mechanism of CMG2 in glioma remain to be elucidated. We assessed the clinicopathological relevance of CMG2 in a cohort of 48 glioma patients as well as through public glioma databases, and explored the function of CMG2 using glioblastoma (GBM) models <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. CMG2 overexpression was associated with increased tumor grade and poor patient survival. CMG2 promoted G2\/M\u2010phase transition during the cell cycle of GBM cells <jats:italic>in vitro<\/jats:italic> and contributed to tumor growth <jats:italic>in vivo<\/jats:italic>. We also observed that CMG2 is implicated in the activation of extracellular signal\u2010regulated kinases (ERKs), epithelial\u2013mesenchymal transition (EMT), migration, and invasion in GBM cells. Transcriptomic analysis of GBM cells with or without CMG2 overexpression indicated that a panel of oncogenic signaling pathways was altered with CMG2 upregulation, implying that CMG2 might orchestrate these signaling pathways to regulate the growth of GBM cells. Yes\u2010associated protein 1 (YAP1) activity was enhanced by CMG2 overexpression but suppressed with CMG2 deficiency. Since YAP1 is critically implicated in GBM, the oncogenic roles of CMG2 in GBM cells might thus be mediated, at least partially, by YAP1. Altogether, CMG2 functioned as an oncogene in glioma cells and is a potential prognostic biomarker or therapeutic target for the clinical treatment of glioma. Copyright \u00a9 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5062","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T03:36:48Z","timestamp":1519357008000},"page":"160-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Capillary morphogenesis protein 2 is a novel prognostic biomarker and plays oncogenic roles in glioma"],"prefix":"10.1002","volume":"245","author":[{"given":"Juan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Chongqing University  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Liang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Rong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Hong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8150-5486","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-0197","authenticated-orcid":false,"given":"Xiu\u2010Wu","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital Third Military Medical University  Chongqing PR China"},{"name":"Key Laboratory of Tumor Immunology and Pathology of Ministry of Education  Chongqing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.15.2755"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.442"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0431098100"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/378781"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/378418"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034862"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.160"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.383"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.20374"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/3806"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2038"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1650-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.06.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.02.023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.223"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70025-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.03.021"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280319"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.03.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2284"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7183"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217730110"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(97)00017-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-323"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1180"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now247"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18610"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712168105"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.23.8213-8224.2001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1596707"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou147"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1835"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3758"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.048"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3876"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6205"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3458"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.192856.112"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881115)62:10<2152::AID-CNCR2820621015>3.0.CO;2-T"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328312c3a7"},{"key":"e_1_2_7_44_1","first-page":"12","article-title":"Update on the 2016 WHO classification of tumors of the central nervous system \u2013 Part 1: Diffusely infiltrating gliomas","volume":"53","author":"Svajdler M","year":"2017","journal-title":"Cesk Patol"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.70"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31821ff8d8"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.722751"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5189"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400647"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0272"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2175"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1066-5"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.4691"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1229"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02244-06"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/cns-2015-0005"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183516"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-31"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.5062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:46:35Z","timestamp":1760964395000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.5062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,2]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/path.5062"],"URL":"https:\/\/doi.org\/10.1002\/path.5062","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[2018,4,2]]},"assertion":[{"value":"2017-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}