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However, it has been difficult to design adequate mouse models for high\u2010grade serous carcinoma (HGSC), the most common and lethal form of ovarian cancer. The genetic complexity of the disease, as well as the recent appreciation that most HGSCs arise from the fallopian tube (FT) secretory epithelium rather than the ovarian surface epithelium, has stifled the development of robust GEMMs. In a recent issue of this journal, Zhai <jats:italic>et al<\/jats:italic> presented an elegant mouse model for ovarian cancer that uses <jats:italic>Ovgp1<\/jats:italic> as an FT\u2010specific promoter to inactivate <jats:italic>Brca1<\/jats:italic>, <jats:italic>Trp53<\/jats:italic>, <jats:italic>Rb1<\/jats:italic>, <jats:italic>Nf1<\/jats:italic>, and <jats:italic>Pten<\/jats:italic>. The authors showed that loss of these genes in the mouse FT epithelium can mimic the different stages of human HGSC tumorigenesis. Their robust model emphasizes the importance of considering both the cell of origin and tumor genetics in developing accurate model systems. They provide a useful tool for studying mechanisms of disease <jats:italic>in vivo<\/jats:italic> and for research into novel methods of prevention, early detection, and treatment of HGSC. Copyright \u00a9 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5065","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T06:47:08Z","timestamp":1519886828000},"page":"129-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Precious GEMMs: emergence of faithful models for ovarian cancer research"],"prefix":"10.1002","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-0120","authenticated-orcid":false,"given":"Sarah","family":"Stuckelberger","sequence":"first","affiliation":[{"name":"Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology University of Pennsylvania Perelman School of Medicine  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-6977","authenticated-orcid":false,"given":"Ronny","family":"Drapkin","sequence":"additional","affiliation":[{"name":"Penn 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