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Thus, damage to the mucosa requires an immediate response to provide appropriate wound closure and healing. Metaplastic lineages with phenotypes similar to the mucous glands of the distal stomach or Brunner's glands have been associated with various injurious scenarios in the stomach, small bowel, and colon. These lineages have been assigned various names including pyloric metaplasia, pseudopyloric metaplasia, ulcer\u2010associated cell lineage (UACL), and spasmolytic polypeptide\u2010expressing metaplasia (SPEM). A re\u2010examination of the literature on these various forms of mucous cell metaplasia suggests that pyloric\u2010type mucosal gland lineages may provide a ubiquitous response to mucosal injury throughout the gastrointestinal tract as well as in the pancreas, esophagus, and other mucosal surfaces. While the cellular origin of these putative reparative lineages likely varies in different regions of the gut, their final phenotypes may converge on a pyloric\u2010type gland dedicated to mucous secretion. In addition to their healing properties in the setting of acute injury, these pyloric\u2010type lineages may also represent precursors to neoplastic transitions in the face of chronic inflammatory influences. Further investigations are needed to determine how discrete molecular profiles relate to the origin and function of pyloric\u2010type metaplasias previously described by histological characteristics in multiple epithelial mucosal systems in the setting of acute and chronic damage. Copyright \u00a9 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5066","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T23:56:40Z","timestamp":1520294200000},"page":"132-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Pyloric metaplasia, pseudopyloric metaplasia, ulcer\u2010associated cell lineage and spasmolytic polypeptide\u2010expressing metaplasia: reparative lineages in the gastrointestinal mucosa"],"prefix":"10.1002","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-2940","authenticated-orcid":false,"given":"James R","family":"Goldenring","sequence":"first","affiliation":[{"name":"Section of Surgical Sciences Vanderbilt University School of Medicine  Nashville TN USA"},{"name":"Epithelial Biology Center Vanderbilt University School of Medicine  Nashville TN USA"},{"name":"Department of Cell and Developmental Biology Vanderbilt University 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