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N\u2010WASP mediates invasion of cancer cells <jats:italic>in vitro<\/jats:italic> and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we explored a role for N\u2010WASP in the initiation and progression of colorectal cancer. While deletion of <jats:italic>N\u2010wasp<\/jats:italic> is not detectably harmful in the murine intestinal tract, numbers of Paneth cells increased, indicating potential changes in the stem cell niche, and migration up the crypt\u2013villus axis was enhanced. Loss of <jats:italic>N\u2010wasp<\/jats:italic> promoted adenoma formation in an adenomatous polyposis coli (<jats:italic>Apc<\/jats:italic>) deletion model of intestinal tumourigenesis. Thus, we establish a tumour suppressive role of N\u2010WASP in early intestinal carcinogenesis despite its later pro\u2010invasive role in other cancers. 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