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Van Gogh\u2010like 2 (Vangl2) is a key PCP protein that is required for the normal differentiation of kidney glomeruli and tubules. Vangl2 has also been implicated in modifying the course of acquired glomerular disease, and here, we further explored how Vangl2 impacts on glomerular pathobiology in this context. Targeted genetic deletion of <jats:italic>Vangl2<\/jats:italic> in mouse glomerular epithelial podocytes enhanced the severity of not only irreversible accelerated nephrotoxic nephritis but also lipopolysaccharide\u2010induced reversible glomerular damage. In each proteinuric model, genetic deletion of <jats:italic>Vangl2<\/jats:italic> in podocytes was associated with an increased ratio of active\u2010MMP9 to inactive MMP9, an enzyme involved in tissue remodelling. In addition, by interrogating microarray data from two cohorts of renal patients, we report increased <jats:italic>VANGL2<\/jats:italic> transcript levels in the glomeruli of individuals with focal segmental glomerulosclerosis, suggesting that the molecule may also be involved in certain human glomerular diseases. These observations support the conclusion that Vangl2 modulates glomerular injury, at least in part by acting as a brake on MMP9, a potentially harmful endogenous enzyme. \u00a9 2018 The Authors. <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.5158","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T06:59:47Z","timestamp":1534748387000},"page":"485-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury"],"prefix":"10.1002","volume":"246","author":[{"given":"Eugenia","family":"Papakrivopoulou","sequence":"first","affiliation":[{"name":"Developmental Biology and Cancer Programme UCL Great Ormond Street Institute of Child Health  London 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