{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:31:34Z","timestamp":1792899094849,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12\u2010HD000849"],"award-info":[{"award-number":["K12\u2010HD000849"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01\u2010CA156021"],"award-info":[{"award-number":["U01\u2010CA156021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013401","name":"Ovarian Cancer Research Fund Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011338","name":"AstraZeneca Schweiz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003769","name":"Foundation for Women's Wellness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001036","name":"Claneil Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003135","name":"Minnesota Ovarian Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006800","name":"Honorable Tina Brozman Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006800","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucinous ovarian tumors (MOTs) morphologically and epidemiologically resemble mucinous cystic neoplasms (MCNs) of the pancreas, sharing a similar stroma and both occurring disproportionately among young females. Additionally, MOTs and MCNs share similar clinical characteristics and immunohistochemical phenotypes. Exome sequencing has revealed frequent recurrent mutations in <jats:italic>KRAS<\/jats:italic> and <jats:italic>RNF43<\/jats:italic> in both MOTs and MCNs. The cell of origin for these tumors remains unclear, but MOTs sometimes arise in the context of mature cystic teratomas and other primordial germ cell (PGC) tumors. We undertook the present study to investigate whether non\u2010teratoma\u2010associated MOTs and MCNs share a common cell of origin. Comparisons of the gene expression profiles of MOTs [including both the mucinous borderline ovarian tumors (MBOTs) and invasive mucinous ovarian carcinomas (MOCs)], high\u2010grade serous ovarian carcinomas, ovarian surface epithelium, Fallopian tube epithelium, normal pancreatic tissue, pancreatic duct adenocarcinomas, MCNs, and single\u2010cell RNA\u2010sequencing of PGCs revealed that both MOTs and MCNs are more closely related to PGCs than to either eutopic epithelial tumors or normal epithelia. We hypothesize that MCNs may arise from PGCs that stopped in the dorsal pancreas during their descent to the gonads during early human embryogenesis, while MOTs arise from PGCs in the ovary. Together, these data suggest a common pathway for the development of MCNs and MOTs, and suggest that these tumors may be more properly classified as germ cell tumor variants. Copyright \u00a9 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5161","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T08:25:00Z","timestamp":1537345500000},"page":"459-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors"],"prefix":"10.1002","volume":"246","author":[{"given":"Kevin M","family":"Elias","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology Brigham and Women's Hospital  Boston MA USA"},{"name":"Division of Gynecologic Oncology Dana\u2010Farber Cancer Institute  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Tsantoulis","sequence":"additional","affiliation":[{"name":"Department of internal medicine specialties Facutly of Medicine, Universit\u00e9 de Gen\u00e8ve  Geneva Switzerland"},{"name":"Department of Oncology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Tille","sequence":"additional","affiliation":[{"name":"Division of Pathology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Vitonis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona A","family":"Doyle","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA USA"},{"name":"Department of Pathology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L","family":"Hornick","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA USA"},{"name":"Department of Pathology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurkan","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of internal medicine specialties Facutly of Medicine, Universit\u00e9 de Gen\u00e8ve  Geneva Switzerland"},{"name":"Division of Dermatology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Dermatology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Cramer","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA USA"},{"name":"Department of Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Puppa","sequence":"additional","affiliation":[{"name":"Division of Pathology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-0120","authenticated-orcid":false,"given":"Sarah","family":"Stuckelberger","sequence":"additional","affiliation":[{"name":"Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagmohan","family":"Hooda","sequence":"additional","affiliation":[{"name":"Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Yves","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of internal medicine specialties Facutly of Medicine, Universit\u00e9 de Gen\u00e8ve  Geneva Switzerland"},{"name":"Department of Oncology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-2296","authenticated-orcid":false,"given":"Michael","family":"Goggins","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace L","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Maryland  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Birrer","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2013Oncology University of Alabama at Birmingham Comprehensive Cancer Center  Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA USA"},{"name":"Department of Pathology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-6977","authenticated-orcid":false,"given":"Ronny","family":"Drapkin","sequence":"additional","affiliation":[{"name":"Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-3475","authenticated-orcid":false,"given":"Sana Intidhar","family":"Labidi\u2010Galy","sequence":"additional","affiliation":[{"name":"Department of internal medicine specialties Facutly of Medicine, Universit\u00e9 de Gen\u00e8ve  Geneva Switzerland"},{"name":"Department of Oncology H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200307000-00014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828f9ecb"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i45.5682"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31811f4449"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181f749d3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4134"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118046108"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-85729-826-3_2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039088"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1110"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208117"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4959"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.07.016"},{"key":"e_1_2_7_18_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg405"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(03)00140-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxr034"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.6026\/97320630002428"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017300108"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.12.011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-014-0389-x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.10.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00962-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182299c25"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0b013e3181584643"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382184-3.00005-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5146"},{"key":"e_1_2_7_36_1","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman F","year":"2010"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.03.007"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200007000-00007"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000733"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/35101096"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001871"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.584"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.15"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.5161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.5161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/path.5161","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:37:07Z","timestamp":1760971027000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.5161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/path.5161"],"URL":"https:\/\/doi.org\/10.1002\/path.5161","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]},"assertion":[{"value":"2017-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}