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Our cohort included cases with MZ lymphomas (<jats:italic>n<\/jats:italic> = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (<jats:italic>n<\/jats:italic> = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross\u2010entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ\u2010related or not; <jats:italic>n<\/jats:italic> = 65 837) revealed four major clusters of cases sharing homologous (\u2018public\u2019) heavy variable complementarity\u2010determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non\u2010malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen\u2010triggered, immune\u2010mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and\/or operating in particular microenvironments. Copyright \u00a9 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5209","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T11:34:10Z","timestamp":1543404850000},"page":"416-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Disease\u2010biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations"],"prefix":"10.1002","volume":"247","author":[{"given":"Aliki","family":"Xochelli","sequence":"first","affiliation":[{"name":"Institute of Applied Biosciences CERTH  Thessaloniki Greece"},{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Bikos","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Polychronidou","sequence":"additional","affiliation":[{"name":"Information Technologies Institute, CERTH  Thessaloniki Greece"},{"name":"Department of Informatics Ionian University  Corfu Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysi","family":"Galigalidou","sequence":"additional","affiliation":[{"name":"Institute of Applied Biosciences CERTH  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Agathangelidis","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology and Department of Onco\u2010Hematology IRCCS San Raffaele Scientific Institute and Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Charlotte","sequence":"additional","affiliation":[{"name":"Department of Pathology Hopital Pitie\u2010Salpetriere and Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Moschonas","sequence":"additional","affiliation":[{"name":"Information Technologies Institute, CERTH  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zadie","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Bournemouth Hospital  Bournemouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Colombo","sequence":"additional","affiliation":[{"name":"Molecular Pathology, Ospedale Policlinico SanMartino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Roumelioti","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic Medicine University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley\u2010Ann","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Groenen","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"van den Brand","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Boudjoghra","sequence":"additional","affiliation":[{"name":"Department of Hematology Hopital Pitie\u2010Salpetriere and Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Algara","sequence":"additional","affiliation":[{"name":"Hospital Virgen de la Salud  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Traverse\u2010Glehen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Hematology Hospices Civils de Lyon Universite Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Laboratori de Citologia Hematol\u00f2gica i Citogen\u00e8tica Molecular Servei de Patologia, Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Stalika","sequence":"additional","affiliation":[{"name":"Institute of Applied Biosciences CERTH  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Karypidou","sequence":"additional","affiliation":[{"name":"Hematology Department and HCT Unit G. 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