{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:56:30Z","timestamp":1773158190049,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA046592"],"award-info":[{"award-number":["P30CA046592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most high\u2010grade serous carcinomas are thought to arise from Fallopian tube epithelium (FTE), but some likely arise outside of the tube, perhaps from ectopic tubal\u2010type epithelium known as endosalpingiosis. Importantly, the origin of endosalpingiosis is poorly understood. The proximity of the tubal fimbriae to the ovaries has led to the proposal that disruptions in the ovarian surface that occur during ovulation may allow detached FTE to implant in the ovary and form tubal\u2010type glands and cysts. An alternative model suggests that cells present in ectopic locations outside the M\u00fcllerian tract retain the capacity for multi\u2010lineage differentiation and can form glands with tubal\u2010type epithelium. We used double transgenic <jats:italic>Ovgp1\u2010iCreER<\/jats:italic><jats:sup><jats:italic>T2<\/jats:italic><\/jats:sup><jats:italic>;R26R<\/jats:italic><jats:sup><jats:italic>LSL\u2010eYFP<\/jats:italic><\/jats:sup> mice, which express an eYFP reporter protein in OVGP1\u2010positive tissues following transient tamoxifen (TAM) treatment, to track the fate of oviductal epithelial cells. Cohorts of adult mice were given TAM to activate eYFP expression in oviductal epithelium, and ovaries were examined at time points ranging from 2\u2009days to 12\u2009months post\u2010TAM. To test whether superovulation might increase acquisition of endosalpingiosis, additional cohorts of TAM\u2010treated mice underwent up to five cycles of superovulation and ovaries were examined at 1, 6, and 12\u2009months post\u2010TAM. Ovaries were sectioned in their entirety to identify endosalpingiosis. Immunohistochemical staining for PAX8, tubulin, OVGP1, and eYFP was employed to study endosalpingiosis lesions. Ovarian endosalpingiosis was identified in 14.2% of TAM\u2010treated adult mice. The endosalpingiotic inclusion glands and cysts were lined by secretory and ciliated cells and expressed PAX8, tubulin, OVGP1, and eYFP. Neither age nor superovulation was associated with a significant increase in endosalpingiosis. Endosalpingiosis was also occasionally present in the ovaries of pre\u2010pubertal mice. The findings imply that ovarian endosalpingiosis in the mouse does not likely arise as a consequence of detachment and implantation of tubal epithelium and other mechanisms may be relevant. \u00a9 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5308","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T06:18:48Z","timestamp":1558937928000},"page":"206-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium"],"prefix":"10.1002","volume":"249","author":[{"given":"Yisheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor MI USA"},{"name":"Obstetrics &amp; Gynecology Hospital of Fudan University  Shanghai PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S","family":"Sessine","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Tipton","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"McCool","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rork","family":"Kuick","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise 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