{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:38:30Z","timestamp":1761093510726,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000625","name":"Great Britain Sasakawa Foundation","doi-asserted-by":"publisher","award":["B95"],"award-info":[{"award-number":["B95"]}],"id":[{"id":"10.13039\/501100000625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The progress of antisense\u2010based therapies using first generation Morpholino oligonucleotides for Duchenne muscular dystrophy (DMD) is expected to partially restore dystrophin expression and may prolong the lifespan of DMD patients. In a recent issue of <jats:italic>The Journal of Pathology<\/jats:italic>, a sophisticated study by Vila <jats:italic>et al<\/jats:italic> used a dystrophic mouse model of DMD to demonstrate that Morpholino\u2010induced exon skipping induced dystrophin expression in skeletal muscle and stimulated cell mediated and humoral responses to dystrophin. The study highlights the need to further investigate the autoimmune response against <jats:italic>de novo<\/jats:italic> synthesised truncated dystrophin protein and its long\u2010term consequences after exon\u2010skipping therapy for DMD. \u00a9 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5327","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T10:53:38Z","timestamp":1563533618000},"page":"271-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmune response and its long\u2010term consequences after exon\u2010skipping therapy in a Duchenne muscular dystrophy mouse model"],"prefix":"10.1002","volume":"249","author":[{"given":"Joel Z","family":"Nordin","sequence":"first","affiliation":[{"name":"Department of Molecular Therapy National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"},{"name":"Department of Laboratory Medicine Clinical Research Center, Karolinska Institutet, Karolinska University Hospital  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-7506","authenticated-orcid":false,"given":"Yoshitsugu","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,31]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5263"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0713"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000228"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2013.092"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.09.001"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.77976"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0344-3"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.5327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.5327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:51:28Z","timestamp":1761047488000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.5327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,31]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/path.5327"],"URL":"https:\/\/doi.org\/10.1002\/path.5327","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[2019,8,31]]},"assertion":[{"value":"2019-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}