{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:11:18Z","timestamp":1761052278735,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Klebsiella pneumoniae<\/jats:italic><\/jats:styled-content> is a Gram\u2010negative bacterium that is increasingly difficult to treat due to the emergence of multidrug resistant strains. In a recent article, Ding <jats:italic>et al<\/jats:italic> demonstrate that prekallikrein depletion in mice followed by intranasal instillation of <jats:styled-content style=\"fixed-case\"><jats:italic>K. pneumoniae<\/jats:italic><\/jats:styled-content> leads to a reduced bacterial burden and prolonged host survival, together with evidence of reduced distant organ damage. These effects are apparently independent of the role of prekallikrein in the contact system, and are associated with transcriptional changes relevant to innate immunity in the lung, established prior to infection. This study highlights the importance of further investigating the role of prekallikrein and other contact cascade components in host defence to counter <jats:styled-content style=\"fixed-case\"><jats:italic>K. pneumoniae<\/jats:italic><\/jats:styled-content> (and perhaps other pathogens), with an overall aim of identifying potential therapeutic targets relevant to pulmonary infection with such resistant pathogens. \u00a9 2020 Pathological Society of Great Britain and Ireland. 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