{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:47:38Z","timestamp":1761162458425,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009268","name":"Alport Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008637","name":"Center for Strategic Scientific Initiatives, National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA227493"],"award-info":[{"award-number":["R01CA227493"]}],"id":[{"id":"10.13039\/100008637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F32DK115109","R01DK104753","R01DK117599","U01DK116101","U54KD083912","UM1DK100846"],"award-info":[{"award-number":["F32DK115109","R01DK104753","R01DK117599","U01DK116101","U54KD083912","UM1DK100846"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In a recent issue of\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    , Iampietro\n                    <jats:italic>et al<\/jats:italic>\n                    isolated and characterized several clones of urine\u2010derived podocytes from three patients with Alport syndrome (AS) and proteinuria and one age\u2010matched non\u2010proteinuric control. They reported differential expression of genes involved in cell motility, adhesion, survival, and angiogenesis. The authors found AS podocytes to be less motile and to have significantly higher permeability to albumin compared to control podocytes, highlighting that AS podocytes may retain their phenotype even when losing contact with the glomerular basement membrane. The establishment of urine\u2010derived podocyte cell lines from patients with different genetic forms of AS may represent a valuable and minimally invasive tool to investigate the cellular mechanisms contributing to kidney disease progression in AS and may allow for the establishment of patient\u2010specific drug screening opportunities. \u00a9 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.5564","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T06:58:50Z","timestamp":1601708330000},"page":"11-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bedside to bench\n                    <scp>Alport syndrome<\/scp>\n                    research: are human urine\u2010derived podocytes the answer?\n                    <sup>\u2020<\/sup>"],"prefix":"10.1002","volume":"253","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-7956","authenticated-orcid":false,"given":"Jin\u2010Ju","family":"Kim","sequence":"first","affiliation":[{"name":"Katz Family Division of Nephrology and Hypertension\/Peggy and Harold Katz Drug Discovery Center, Department of Medicine University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-7773","authenticated-orcid":false,"given":"Alessia","family":"Fornoni","sequence":"additional","affiliation":[{"name":"Katz Family Division of Nephrology and Hypertension\/Peggy and Harold Katz Drug Discovery Center, Department of Medicine University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.15.8767"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022296"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.274449"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv325"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.07.024"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806891"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008101086"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.130.5.1219"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00866"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5496"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.021"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.424"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2007.06.006"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3067-9"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0934-7"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.252"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.01.013"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.5564","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:57:24Z","timestamp":1761065844000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.5564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/path.5564"],"URL":"https:\/\/doi.org\/10.1002\/path.5564","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"assertion":[{"value":"2020-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}