{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:40:22Z","timestamp":1761766822585,"version":"build-2065373602"},"reference-count":100,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) was suggested as an entity separate from other types of Hodgkin lymphoma 40\u2009years ago and recognized in the WHO classification in 2001. Based on its relatively benign course with late distant relapses, relation with lymph node hyperplasia with progressively transformed germinal centers, presence of clonal immunoglobulin gene rearrangements with somatic hypermutations and ongoing mutations, and relation with a number of inherited defects affecting the immune system, it has been suspected that NLPHL might be antigen\u2010driven. Recent evidence has shown that cases of IgD\u2010positive NLPHL are associated with infection by\n                    <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                    , a common bacterium in the upper respiratory tract and in lymph nodes. This review summarizes the evidence for NLPHL as a B\u2010cell lymphoma involving follicular T\u2010lymphocytes normally found in germinal centers, its molecular features and relation to inherited immune defects, and its relation and differential diagnosis from similar entities. Finally, it discusses the evidence that in many cases a watch and wait policy might be a viable initial management strategy. \u00a9 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.5567","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T16:37:58Z","timestamp":1602520678000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lymphocyte predominant\n                    <scp>Hodgkin<\/scp>\n                    lymphoma, antigen\u2010driven after all?"],"prefix":"10.1002","volume":"253","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9054-5375","authenticated-orcid":false,"given":"Sibrandes","family":"Poppema","sequence":"first","affiliation":[{"name":"School of Medical and Health Sciences Sunway University  Bandar Sunway Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240503"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196603)19:3<317::AID-CNCR2820190304>3.0.CO;2-O"},{"key":"e_1_2_19_4_1","first-page":"19","article-title":"Lymphocyten und ihre funktionsformen morphologie, organization und immunologische bedeutung","volume":"69","author":"Lennert K","year":"1975","journal-title":"Verh Anat Ges"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1979.tb03011.x"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889938"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00411110"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.6777426"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197810)42:4<1793::AID-CNCR2820420418>3.0.CO;2-L"},{"key":"e_1_2_19_10_1","first-page":"1281","article-title":"L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light\u2010chain restriction","volume":"139","author":"Schmid C","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_19_11_1","first-page":"334","article-title":"Light\u2010chain mRNA in lymphocyte\u2010predominant and mixed\u2010cellularity Hodgkin's disease","volume":"9","author":"Wasielewski R","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9337"},{"key":"e_1_2_19_13_1","first-page":"457","article-title":"Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma","volume":"54","author":"Timens W","year":"1986","journal-title":"Lab Invest"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000194741.87798.45"},{"key":"e_1_2_19_15_1","first-page":"5075","volume-title":"Hematopathology","author":"Feldman AL","year":"2017"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00092.x"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200006000-00010"},{"key":"e_1_2_19_18_1","first-page":"1889","article-title":"European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes","volume":"96","author":"Anagnostopoulos I","year":"2000","journal-title":"Blood"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198801000-00002"},{"key":"e_1_2_19_20_1","first-page":"1","article-title":"Hodgkin's disease, lymphocyte predominance type, nodular \u2013 a distinct entity? 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