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Each EC variant has distinct molecular abnormalities, including TCGA\u2010based molecular subtypes, allowing further subclassification and adding complexity. In contrast to this rapid progress in understanding EC, there are only two recognized EC precursor lesions: endometrial atypical hyperplasia\/endometrioid intraepithelial neoplasia (EAH\/EIN) and serous intraepithelial carcinoma, a situation that has not changed for many years. Diagnosis of EC precursors is a cornerstone of surgical pathology practice, with early diagnosis contributing to the relatively favorable prognosis of EC. In this review we relate the precursor lesions to each of the EC morphological variants and molecular subtypes, discuss how successful early diagnosis is for each variant\/molecular subtype and how it might be improved, and identify knowledge gaps where there is insufficient understanding of EC histogenesis. \u00a9 2020 The Pathological Society of Great Britain and Ireland. 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