{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:11:09Z","timestamp":1772993469353,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR57"],"award-info":[{"award-number":["SFB TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Pathol."],"DOI":"10.1002\/path.5643","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T17:16:38Z","timestamp":1613582198000},"source":"Crossref","is-referenced-by-count":2,"title":["Dual proteotoxic stress accelerates liver injury via activation of\n            <scp>p62\u2010Nrf2<\/scp>"],"prefix":"10.1002","author":[{"given":"Deniz","family":"Kuscuoglu","sequence":"first","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Bewersdorf","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6kce","family":"Kobazi Ensari","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanishka","family":"Hittatiya","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Golob\u2010Schwarzl","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University Hospital Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf E","family":"Leube","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Anatomy RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Preisinger","sequence":"additional","affiliation":[{"name":"Proteomics Facility, Interdisciplinary Centre for Clinical Research (IZKF), Medical School RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayada","family":"Metwally","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Eslam","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Lampertico","sequence":"additional","affiliation":[{"name":"CRC \u2018A. M. e A. Migliavacca\u2019 Center for Liver Disease Division of Gastroenterology and Hepatology Fondazione IRCCS Ca' Granda \u2013 Ospedale Maggiore Policlinico Universit\u00e0 di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Petta","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia e Epatologia, DiBiMIS University of Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Mangia","sequence":"additional","affiliation":[{"name":"Division of Hepatology Ospedale Casa Sollievo della Sofferenza, IRCCS  San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Section of Hepatology, Clinic for Gastroenterology and Rheumatology University Clinic Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Boonstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC \u2010 University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem P","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC \u2010 University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lorena","family":"Abate","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medical Science University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Loglio","sequence":"additional","affiliation":[{"name":"CRC \u2018A. M. e A. Migliavacca\u2019 Center for Liver Disease Division of Gastroenterology and Hepatology Fondazione IRCCS Ca' Granda \u2013 Ospedale Maggiore Policlinico Universit\u00e0 di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Sutton","sequence":"additional","affiliation":[{"name":"Centre de Ressources Biologiques (Liver Disease Biobank) Groupe Hospitalier Paris  Seine\u2010Saint\u2010Denis France"},{"name":"AP\u2010HP H\u00f4pital Jean Verdier, Service de Biochimie  Bondy France"},{"name":"Inserm U1148, Universit\u00e9 Paris 13  Bobigny France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Nahon","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Jean Verdier, Service d'H\u00e9patologie  Bondy France"},{"name":"Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9, \u2018Equipe Labellis\u00e9e Ligue Contre le Cancer\u2019  Saint\u2010Denis France"},{"name":"Inserm, UMR\u20101162, \u2018G\u00e9nomique Fonctionnelle des Tumeur Solides\u2019  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Zoller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmar","family":"Aigner","sequence":"additional","affiliation":[{"name":"First Department of Medicine Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Haybaeck","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Faculty Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"},{"name":"Department of Pathology, Neuropathology and Molecular Pathology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-6379","authenticated-orcid":false,"given":"Pavel","family":"Strnad","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-biochem-061516-044518","article-title":"Protein misfolding diseases","volume":"86","author":"Hartl FU","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/cphy.c120032","article-title":"Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models","volume":"3","author":"Strnad P","year":"2013","journal-title":"Compr Physiol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jhep.2018.04.018","article-title":"Liver \u2013 master and servant of serum proteome","volume":"69","author":"Kuscuoglu D","year":"2018","journal-title":"J Hepatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"Wang M","year":"2016","journal-title":"Nature"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1053\/j.gastro.2015.09.042","article-title":"Regulation of liver metabolism by autophagy","volume":"150","author":"Madrigal\u2010Matute J","year":"2016","journal-title":"Gastroenterology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jhep.2016.03.010","article-title":"Update on alpha\u20101 antitrypsin deficiency: new therapies","volume":"65","author":"Lomas DA","year":"2016","journal-title":"J Hepatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1056\/NEJMra1910234","article-title":"Alpha1\u2010antitrypsin deficiency","volume":"382","author":"Strnad P","year":"2020","journal-title":"N Engl J Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1586\/17474124.2014.943187","article-title":"Alpha\u20101 antitrypsin and liver disease: mechanisms of injury and novel interventions","volume":"9","author":"Teckman JH","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.2147\/COPD.S137852","article-title":"Alpha\u20101 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide","volume":"12","author":"Blanco I","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"16051","DOI":"10.1038\/nrdp.2016.51","article-title":"alpha1\u2010antitrypsin deficiency","volume":"2","author":"Greene CM","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1056\/NEJMcp0900449","article-title":"Clinical practice. Alpha1\u2010antitrypsin deficiency","volume":"360","author":"Silverman EK","year":"2009","journal-title":"N Engl J Med"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/j.gastro.2019.05.013","article-title":"Liver fibrosis and metabolic alterations in adults with alpha\u20101\u2010antitrypsin deficiency caused by the Pi*ZZ mutation","volume":"157","author":"Hamesch K","year":"2019","journal-title":"Gastroenterology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/j.gastro.2020.04.058","article-title":"Liver phenotypes of European adults heterozygous or homozygous for Pi *Z variant of AAT (Pi *MZ vs Pi *ZZ genotype) and noncarriers","volume":"159","author":"Schneider CV","year":"2020","journal-title":"Gastroenterology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1001\/jama.2009.1295","article-title":"Genetic modifiers of liver disease in cystic fibrosis","volume":"302","author":"Bartlett JR","year":"2009","journal-title":"JAMA"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa1712191","article-title":"A protein\u2010truncating HSD17B13 variant and protection from chronic liver disease","volume":"378","author":"Abul\u2010Husn NS","year":"2018","journal-title":"N Engl J Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/gutjnl-2018-316228","article-title":"Heterozygous carriage of the alpha1\u2010antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis","volume":"68","author":"Strnad P","year":"2019","journal-title":"Gut"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.7326\/0003-4819-117-8-641","article-title":"High prevalence of viral infection in adults with homozygous and heterozygous alpha 1\u2010antitrypsin deficiency and chronic liver disease","volume":"117","author":"Propst T","year":"1992","journal-title":"Ann Intern Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1172\/JCI113999","article-title":"Accumulation of PiZ alpha 1\u2010antitrypsin causes liver damage in transgenic mice","volume":"83","author":"Carlson JA","year":"1989","journal-title":"J Clin Invest"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1190354","article-title":"An autophagy\u2010enhancing drug promotes degradation of mutant alpha1\u2010antitrypsin Z and reduces hepatic fibrosis","volume":"329","author":"Hidvegi T","year":"2010","journal-title":"Science"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 Clinical practice guidelines on the management of hepatitis B virus infection","volume":"67","author":"European Association for the Study of the Liver","year":"2017","journal-title":"J Hepatol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/path.4434","article-title":"The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets","volume":"235","author":"Ringelhan M","year":"2015","journal-title":"J Pathol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000343857","article-title":"Quantitative levels of hepatitis B virus DNA and surface antigen and the risk of hepatocellular carcinoma in patients with hepatitis B receiving long\u2010term nucleos(t)ide analogue therapy","volume":"3","author":"Kawanaka M","year":"2014","journal-title":"Liver Cancer"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/hep.26041","article-title":"Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads","volume":"57","author":"Tseng TC","year":"2013","journal-title":"Hepatology"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/JVI.60.3.880-887.1986","article-title":"Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice","volume":"60","author":"Chisari FV","year":"1986","journal-title":"J Virol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0092-8674(89)90770-8","article-title":"Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice","volume":"59","author":"Chisari FV","year":"1989","journal-title":"Cell"},{"key":"e_1_2_7_27_1","first-page":"3400","article-title":"Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice","volume":"50","author":"Dunsford HA","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa P","year":"1996","journal-title":"Hepatology"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jhep.2016.04.024","article-title":"Keratin 23 is a stress\u2010inducible marker of mouse and human ductular reaction in liver disease","volume":"65","author":"Guldiken N","year":"2016","journal-title":"J Hepatol"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and aging","volume":"21","author":"Kaushik S","year":"2015","journal-title":"Nat Med"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet\u2010associated proteins by chaperone\u2010mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik S","year":"2015","journal-title":"Nat Cell Biol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxlet.2017.09.015","article-title":"An integrative analysis of chemically\u2010induced cirrhosis\u2010associated hepatocarcinogenesis: histological, biochemical and molecular features","volume":"281","author":"Romualdo GR","year":"2017","journal-title":"Toxicol Lett"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molcel.2011.06.038","article-title":"p62 is a key regulator of nutrient sensing in the mTORC1 pathway","volume":"44","author":"Duran A","year":"2011","journal-title":"Mol Cell"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ccell.2016.04.006","article-title":"p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC\u2010initiating cells","volume":"29","author":"Umemura A","year":"2016","journal-title":"Cancer Cell"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.hepres.2005.09.035","article-title":"High prevalence of alpha 1 antitrypsin phenotypes in viral hepatitis B infected patients in Iran","volume":"33","author":"Hashemi M","year":"2005","journal-title":"Hepatol Res"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/S0140-6736(14)60220-8","article-title":"Hepatitis B virus infection","volume":"384","author":"Tr\u00e9po C","year":"2014","journal-title":"Lancet"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/hep.23806","article-title":"Glucosidase inhibition enhances presentation of de\u2010N\u2010glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks","volume":"52","author":"Norton PA","year":"2010","journal-title":"Hepatology"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1515\/BC.1999.042","article-title":"Chaperones involved in hepatitis B virus morphogenesis","volume":"380","author":"Prange R","year":"1999","journal-title":"Biol Chem"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1091\/mbc.e07-06-0587","article-title":"Sequestration of mutated alpha1\u2010antitrypsin into inclusion bodies is a cell\u2010protective mechanism to maintain endoplasmic reticulum function","volume":"19","author":"Granell S","year":"2008","journal-title":"Mol Biol Cell"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"7946","DOI":"10.1074\/jbc.272.12.7946","article-title":"Intracellular disposal of incompletely folded human alpha1\u2010antitrypsin involves release from calnexin and post\u2010translational trimming of asparagine\u2010linked oligosaccharides","volume":"272","author":"Liu Y","year":"1997","journal-title":"J Biol Chem"},{"key":"e_1_2_7_41_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nature07195","article-title":"Misfolded proteins partition between two distinct quality control compartments","volume":"454","author":"Kaganovich D","year":"2008","journal-title":"Nature"},{"key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate M","year":"2004","journal-title":"Nature"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.arr.2018.11.006","article-title":"Targeting the proteostasis network in Huntington's disease","volume":"49","author":"Soares TR","year":"2019","journal-title":"Ageing Res Rev"},{"key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"e11792","DOI":"10.7554\/eLife.11792","article-title":"Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex","volume":"5","author":"Yang J","year":"2016","journal-title":"Elife"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/15548627.2017.1319544","article-title":"The constitutive lipid droplet protein PLIN2 regulates autophagy in liver","volume":"13","author":"Tsai TH","year":"2017","journal-title":"Autophagy"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cmet.2015.12.015","article-title":"Obesity and cancer: the oil that feeds the flame","volume":"23","author":"Font\u2010Burgada J","year":"2016","journal-title":"Cell Metab"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat J","year":"2009","journal-title":"Cell"},{"key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu M","year":"2010","journal-title":"Nat Cell Biol"},{"key":"e_1_2_7_49_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.trsl.2017.11.007","article-title":"Nrf2\u2010p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma","volume":"193","author":"Bartolini D","year":"2018","journal-title":"Transl Res"},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF\u2010dependent spontaneous HCC development","volume":"26","author":"Nakagawa H","year":"2014","journal-title":"Cancer Cell"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ccr.2008.06.016","article-title":"Hepatocyte necrosis induced by oxidative stress and IL\u20101 alpha release mediate carcinogen\u2010induced compensatory proliferation and liver tumorigenesis","volume":"14","author":"Sakurai T","year":"2008","journal-title":"Cancer Cell"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/ng.3421","article-title":"NRF2 regulates serine biosynthesis in non\u2010small cell lung cancer","volume":"47","author":"DeNicola GM","year":"2015","journal-title":"Nat Genet"},{"key":"e_1_2_7_53_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","article-title":"Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming","volume":"22","author":"Mitsuishi Y","year":"2012","journal-title":"Cancer Cell"},{"key":"e_1_2_7_54_1","unstructured":"NCT03945292. Safety tolerability and effect on liver histologic parameters of ARO\u2010AAT. Available from:https:\/\/ClinicalTrials.gov\/show\/NCT03945292. [Accessed 5 March 2020]."},{"key":"e_1_2_7_55_1","unstructured":"NCT03772249. Study of safety and tolerability of DCR HBVS. Available from:https:\/\/ClinicalTrials.gov\/show\/NCT03772249. [Accessed 5 March 2020]."},{"key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCGENETICS.114.000974","article-title":"Desmoglein 2\u2010dependent arrhythmogenic cardiomyopathy is caused by a loss of adhesive function","volume":"8","author":"Kant S","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"e_1_2_7_57_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jhep.2014.04.034","article-title":"Hepcidin knockout mice fed with iron\u2010rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload","volume":"61","author":"Lunova M","year":"2014","journal-title":"J Hepatol"},{"key":"e_1_2_7_58_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1083\/jcb.78.2.349","article-title":"Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient","volume":"78","author":"Wattiaux R","year":"1978","journal-title":"J Cell Biol"},{"key":"e_1_2_7_59_1","doi-asserted-by":"crossref","first-page":"26540","DOI":"10.1074\/jbc.M203832200","article-title":"Detection of circulating and endothelial cell polymers of Z and wild type alpha 1\u2010antitrypsin by a monoclonal antibody","volume":"277","author":"Janciauskiene S","year":"2002","journal-title":"J Biol Chem"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.5643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T04:46:26Z","timestamp":1616129186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/path.5643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":58,"alternative-id":["10.1002\/path.5643"],"URL":"https:\/\/doi.org\/10.1002\/path.5643","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"article-number":"path.5643"}}