{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:27:29Z","timestamp":1780640849499,"version":"3.54.1"},"reference-count":104,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015803","name":"BC Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009794","name":"Breast Cancer Now","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["12\/RIG\/1\u201017"],"award-info":[{"award-number":["12\/RIG\/1\u201017"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["15\/RIG\/1\u201016"],"award-info":[{"award-number":["15\/RIG\/1\u201016"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["operating grant"],"award-info":[{"award-number":["operating grant"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 8699\/1\u20101"],"award-info":[{"award-number":["HE 8699\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["742432"],"award-info":[{"award-number":["742432"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07\u2010CA80668"],"award-info":[{"award-number":["K07\u2010CA80668"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["N01\u2010CN\u201025403\/CN"],"award-info":[{"award-number":["N01\u2010CN\u201025403\/CN"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["N01\u2010CN\u201067001\/CN"],"award-info":[{"award-number":["N01\u2010CN\u201067001\/CN"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u2010CA\u201071789\/CA"],"award-info":[{"award-number":["P30\u2010CA\u201071789\/CA"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA126841"],"award-info":[{"award-number":["R01 CA126841"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01\u2010CA\u201058598\/CA"],"award-info":[{"award-number":["R01\u2010CA\u201058598\/CA"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA095023"],"award-info":[{"award-number":["R01CA095023"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["MO1\u2010 RR000056"],"award-info":[{"award-number":["MO1\u2010 RR000056"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["310670"],"award-info":[{"award-number":["310670"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["628903"],"award-info":[{"award-number":["628903"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"publisher","award":["COEUR support"],"award-info":[{"award-number":["COEUR support"]}],"id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["DAMD17\u201002\u20101\u20100669"],"award-info":[{"award-number":["DAMD17\u201002\u20101\u20100669"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    ARID1A (BAF250a) is a component of the SWI\/SNF chromatin modifying complex, plays an important tumour suppressor role, and is considered prognostic in several malignancies. However, in ovarian carcinomas there are contradictory reports on its relationship to outcome, immune response, and correlation with clinicopathological features. We assembled a series of 1623 endometriosis\u2010associated ovarian carcinomas, including 1078 endometrioid (ENOC) and 545 clear cell (CCOC) ovarian carcinomas, through combining resources of the Ovarian Tumor Tissue Analysis (OTTA) Consortium, the Canadian Ovarian Unified Experimental Resource (COEUR), local, and collaborative networks. Validated immunohistochemical surrogate assays for\n                    <jats:italic>ARID1A<\/jats:italic>\n                    mutations were applied to all samples. We investigated associations between ARID1A loss\/mutation, clinical features, outcome, CD8\n                    <jats:sup>+<\/jats:sup>\n                    tumour\u2010infiltrating lymphocytes (CD8\n                    <jats:sup>+<\/jats:sup>\n                    TILs), and DNA mismatch repair deficiency (MMRd). ARID1A loss was observed in 42% of CCOCs and 25% of ENOCs. We found no associations between ARID1A loss and outcomes, stage, age, or CD8\n                    <jats:sup>+<\/jats:sup>\n                    TIL status in CCOC. Similarly, we found no association with outcome or stage in endometrioid cases. In ENOC, ARID1A loss was more prevalent in younger patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) and was associated with MMRd (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and the presence of CD8\n                    <jats:sup>+<\/jats:sup>\n                    TILs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). Consistent with MMRd being causative of\n                    <jats:italic>ARID1A<\/jats:italic>\n                    mutations, in a subset of ENOCs we also observed an association with\n                    <jats:italic>ARID1A<\/jats:italic>\n                    loss\u2010of\u2010function mutation as a result of small indels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035, versus single nucleotide variants). In ENOC, the association with ARID1A loss, CD8\n                    <jats:sup>+<\/jats:sup>\n                    TILs, and age appears confounded by MMRd status. Although this observation does not explicitly rule out a role for ARID1A influence on CD8\n                    <jats:sup>+<\/jats:sup>\n                    TIL infiltration in ENOC, given current knowledge regarding MMRd, it seems more likely that effects are dominated by the hypermutation phenotype. This large dataset with consistently applied biomarker assessment now provides a benchmark for the prevalence of\n                    <jats:italic>ARID1A<\/jats:italic>\n                    loss\u2010of\u2010function mutations in endometriosis\u2010associated ovarian cancers and brings clarity to the prognostic significance. \u00a9 2021 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.5849","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T05:20:30Z","timestamp":1639372830000},"page":"388-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Validated biomarker assays confirm that\n                    <scp>ARID1A<\/scp>\n                    loss is confounded with\n                    <scp>MMR<\/scp>\n                    deficiency,\n                    <scp>\n                      CD8\n                      <sup>+<\/sup>\n                      TIL\n                    <\/scp>\n                    infiltration, and provides no independent prognostic value in endometriosis\u2010associated ovarian carcinomas"],"prefix":"10.1002","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-3780","authenticated-orcid":false,"given":"Karolin","family":"Heinze","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"},{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyebeh M","family":"Nazeran","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"},{"name":"Department of Women's Health University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan S","family":"Cairns","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek S","family":"Chiu","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel CY","family":"Leung","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola S","family":"Meagher","sequence":"additional","affiliation":[{"name":"University of New South Wales, Adult Cancer Program, Lowy Cancer Research Centre  Sydney Australia"},{"name":"University of New South Wales School of Women's and Children's Health  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J","family":"Kennedy","sequence":"additional","affiliation":[{"name":"The University of Sydney, Centre for Cancer Research, The Westmead Institute for Medical Research  Sydney Australia"},{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Boros","sequence":"additional","affiliation":[{"name":"The University of Sydney, Centre for Cancer Research, The Westmead Institute for Medical Research  Sydney Australia"},{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Kommoss","sequence":"additional","affiliation":[{"name":"Medizin Campus Bodensee, Institute of Pathology  Friedrichshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Walter","family":"Vollert","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medizin Campus Bodensee  Friedrichshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Heitz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecologic Oncology Kliniken Essen Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"du Bois","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecologic Oncology Kliniken Essen Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Harter","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecologic Oncology Kliniken Essen Mitte  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Grube","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"},{"name":"Department of Women's Health University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Department of Women's Health University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Staebler","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen, Institute of Pathology and Neuropathology  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix KF","family":"Kommoss","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg, Institute of Pathology  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Heublein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Heidelberg and National Center for Tumor Diseases  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Peter","family":"Sinn","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg, Institute of Pathology  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveena","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology Barts Health National Health Service Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Laslavic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Elishaev","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Olawaiye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Moysich","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Roswell Park Cancer Institute  Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesmary","family":"Modugno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghwa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Westmead Hospital, Tissue Pathology and Diagnostic Oncology  Sydney Australia"},{"name":"University of Sydney  Sydney Australia"},{"name":"Western Sydney University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison H","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney Australia"},{"name":"University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Harnett","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney Australia"},{"name":"Westmead Hospital, Crown Princess Mary Cancer Centre  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"DeFazio","sequence":"additional","affiliation":[{"name":"The University of Sydney, Centre for Cancer Research, The Westmead Institute for Medical Research  Sydney Australia"},{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney Australia"},{"name":"University of Sydney  Sydney Australia"},{"name":"The Daffodil Centre The University of Sydney, A Joint Venture with Cancer Council NSW  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e T","family":"Fortner","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Centre Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Lener","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Centre Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"To\u0142oczko\u2010Grabarek","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Centre Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Cybulski","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Centre Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Gronwald","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics, Physical Diagnostics and Dental Physiotherapy Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Gronwald","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pathology, International Hereditary Cancer Centre Pomeranian Medical University  Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"Coulson","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A","family":"El\u2010Bahrawy","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Hammersmith Hospital Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minouk J","family":"Schoemaker","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology The Institute of Cancer Research  London UK"},{"name":"Division of Breast Cancer Research The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie L","family":"Gorringe","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Melbourne Australia"},{"name":"Peter MacCallum Cancer Centre, Women's Cancer Program  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-4155","authenticated-orcid":false,"given":"Ian","family":"Campbell","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Melbourne Australia"},{"name":"Peter MacCallum Cancer Centre, Cancer Genetics Laboratory, Research Division  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Cook","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics The University of New Mexico  Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A","family":"Gayther","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center, Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Carney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology John A. Burns School of Medicine, University of Hawaii  Honolulu HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii B","family":"Shvetsov","sequence":"additional","affiliation":[{"name":"University of Hawaii Cancer Center, Epidemiology Program  Honolulu HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Y","family":"Hernandez","sequence":"additional","affiliation":[{"name":"University of Hawaii Cancer Center, Epidemiology Program  Honolulu HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne R","family":"Wilkens","sequence":"additional","affiliation":[{"name":"University of Hawaii Cancer Center, Epidemiology Program  Honolulu HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T","family":"Goodman","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantina","family":"Mateoiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska Academy at Gothenburg University, Sahlgrenska Center for Cancer Research  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska Academy at Gothenburg University, Sahlgrenska Center for Cancer Research  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sahlgrenska Academy at Gothenburg University, Sahlgrenska Center for Cancer Research  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda E","family":"Kelemen","sequence":"additional","affiliation":[{"name":"Hollings Cancer Center and Department of Public Health Sciences Medical University of South Carolina  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Gentry\u2010Maharaj","sequence":"additional","affiliation":[{"name":"University College London, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials &amp; Methodology  London UK"},{"name":"University College London, Department of Women's Cancer, Institute for Women's Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Widschwendter","sequence":"additional","affiliation":[{"name":"University of Innsbruck, EUTOPS Institute  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Menon","sequence":"additional","affiliation":[{"name":"University College London, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials &amp; Methodology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L","family":"Bolton","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Division of Oncology Washington University School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Alsop","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitul","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Histopathology Addenbrookes Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Jimenez\u2010Linan","sequence":"additional","affiliation":[{"name":"Department of Histopathology Addenbrookes Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul DP","family":"Pharoah","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge  Cambridge UK"},{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Brenton","sequence":"additional","affiliation":[{"name":"University of Cambridge, Cancer Research UK Cambridge Institute  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L","family":"Cushing\u2010Haugen","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly R","family":"Harris","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Doherty","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, Department of Population Health Sciences University of Utah  Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-8250","authenticated-orcid":false,"given":"Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafull","family":"Ghatage","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Gynecologic Oncology University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Huntsman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"},{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg S","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Gynecologic Oncology University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V","family":"Tinker","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"},{"name":"Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Alberta Department of Laboratory Medicine and Pathology  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L","family":"Goode","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Science Research Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad H","family":"Nelson","sequence":"additional","affiliation":[{"name":"Trev &amp; Joyce Deeley Research Centre, British Columbia Cancer Agency  Victoria Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J","family":"Ramus","sequence":"additional","affiliation":[{"name":"University of New South Wales, Adult Cancer Program, Lowy Cancer Research Centre  Sydney Australia"},{"name":"University of New South Wales School of Women's and Children's Health  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kommoss","sequence":"additional","affiliation":[{"name":"Department of Women's Health University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Talhouk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"},{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-2037","authenticated-orcid":false,"given":"Martin","family":"K\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-5003","authenticated-orcid":false,"given":"Michael S","family":"Anglesio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of British Columbia  Vancouver Canada"},{"name":"University of British Columbia, Vancouver General Hospital, and BC Cancer. British Columbia's Gynecological Cancer Research Team (OVCARE)  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.23.8879-8888.2000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3744"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1225"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12146"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1895"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009238"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1755-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13551"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008433"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196333"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318212782a"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.982"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182889dc3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4516"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.02.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1169-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31826b5dcc"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.04.040"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7118"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.103"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-015-0811-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.216"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0012-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.161"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38653-0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061710"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2014.25.1.58"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.04.013"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.707612"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e318231f140"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.06.027"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11125120"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.1.59"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.973"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.10.036"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192881"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4599"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.144"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202965"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0338-8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0318-OA"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001020"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317725834"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11524"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4421"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12977"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.017"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.07.005"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3290"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz135"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205129"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.02.009"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1268"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001478"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000274"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.215"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70253-5"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4242-8"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.08.003"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.01.541"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3849"},{"key":"e_1_2_7_65_1","unstructured":"BoltonKL ChanD Corona de la FuenteR et al.Genomic subclasses of ovarian clear cell carcinoma and their impact on disease behavior and outcomes. Unpublished observations 2022."},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28919"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0592-2"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020124"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S207329"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1562"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv428"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.55"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3688"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001798"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2911"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2015.15.3.201"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000199"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.10.008"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.03.008"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0239"},{"key":"e_1_2_7_81_1","article-title":"Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8+ tumor\u2010infiltrating lymphocytes in ovarian cancer","volume":"3","author":"Webb JR","year":"2014","journal-title":"Onco Targets Ther"},{"key":"e_1_2_7_82_1","first-page":"2911","article-title":"Glutamate\u2010cysteine ligase catalytic subunit as a therapeutic target in acute myeloid leukemia and solid tumors","volume":"11","author":"Lin CH","year":"2021","journal-title":"Am J Cancer Res"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-020-00751-3"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.12.009"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081769"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.11.008"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0550"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0076-x"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0532"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-08-0104"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0145"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-60"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl089"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.008"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-5-33"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2744"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1292"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31824c2372"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.337"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3182456ad3"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201945"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0464-9"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0618-9"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000530"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2848"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.5849","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:17:29Z","timestamp":1761067049000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.5849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,7]]},"references-count":104,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/path.5849"],"URL":"https:\/\/doi.org\/10.1002\/path.5849","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.16.21262993","asserted-by":"object"}]},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,7]]},"assertion":[{"value":"2021-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}