{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:33:25Z","timestamp":1780144405195,"version":"3.54.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1P50CA240243\u201001A1"],"award-info":[{"award-number":["1P50CA240243\u201001A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001282","name":"Ovarian Cancer Research Fund","doi-asserted-by":"publisher","award":["650320"],"award-info":[{"award-number":["650320"]}],"id":[{"id":"10.13039\/100001282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201019\u20101\u20100\u20100127"],"award-info":[{"award-number":["W81XWH\u201019\u20101\u20100\u20100127"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current theory of carcinogenesis for the deadliest of \u2018ovarian\u2019 cancers\u2014high\u2010grade serous carcinoma (HGSC)\u2014holds that the malignancy develops first in the fallopian tube and spreads to the ovaries, peritoneum, and\/or regional lymph nodes. This is based primarily on the observation of early forms of serous neoplasia (serous tubal intraepithelial lesions [STILs], and serous tubal intraepithelial carcinomas [STICS]) in the fimbria of women undergoing risk reduction surgery. However, these lesions are uncommon in the general population, confer a low risk (5%) of HGSC following their removal in at\u2010risk women with germ\u2010line <jats:italic>BRCA1\/2<\/jats:italic> mutations, and require 4 or more years to recur as intraperitoneal HGSC. These features suggest that isolated STILs and STICs behave as precursors, with uncertain cancer risk rather than carcinomas. Their evolution to HGSC within, or after, escape from the tube could proceed stepwise with multiple biologic events; however, it is unclear whether tubal or ovarian HGSCs encountered in the setting of advanced disease evolved in the same fashion. The latter scenario could also be explained by a \u2018catastrophic\u2019 model in which STICs suddenly develop with invasive and metastatic potential, overwhelming or obscuring the site of origin. Moreover, a similar model might explain the sudden emergence of HGSC in the peritoneal cavity following escape of precursor cells years before. Long\u2010term follow\u2010up data from opportunistic or prophylactic salpingectomy should shed light on where malignant transformation occurs, as well as the timeline from precursor to metastatic HGSC. \u00a9 2022 The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.5891","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T22:40:16Z","timestamp":1646260816000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention"],"prefix":"10.1002","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-0045","authenticated-orcid":false,"given":"Ju Yoon","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Pathology, Division of Women's and Perinatal Pathology Brigham and Women's Hospital  Boston MA USA"},{"name":"Department of Laboratory Medicine St. Michaels Hospital, Unity Health Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-5442","authenticated-orcid":false,"given":"David B","family":"Chapel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Women's and Perinatal Pathology Brigham and Women's Hospital  Boston MA USA"},{"name":"Department of Pathology University of Michigan Medical Center  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-8926","authenticated-orcid":false,"given":"Emily","family":"Goebel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine London Health Sciences Centre and Western University  ON London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Cytopathology Stanford University Medical Center  Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-4494","authenticated-orcid":false,"given":"Jeffrey K","family":"Mito","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Cytopathology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-0642","authenticated-orcid":false,"given":"Neil S","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Miron","sequence":"additional","affiliation":[{"name":"PlexSeq Diagnostics  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-992X","authenticated-orcid":false,"given":"T Rinda","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wa","family":"Xian","sequence":"additional","affiliation":[{"name":"University of Houston Stem Cell Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-1436","authenticated-orcid":false,"given":"Christopher P","family":"Crum","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Women's and Perinatal Pathology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"HendersonJT WebberEM SawayaGF.Screening for Ovarian Cancer: An Updated Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 157. AHRQ Publication No. 17\u201005231\u2010EF\u20101. Agency for Healthcare Research and Quality: Rockville MD 2018."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.06.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041842"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251900"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11848"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.01.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000715)89:2<383::AID-CNCR25>3.0.CO;2-T"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000195"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010358"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01272.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5623"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1000"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.06.065"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6779"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000187892.78392.3f"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180854.28831.77"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31823b8831"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.12.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.01.029"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.018"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00962-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.197"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"1027","article-title":"Landscape of putative precursors to high grade serous carcinoma (HGSC) in the female genital tract","volume":"30","author":"Chapel D","year":"2020","journal-title":"Mod Pathol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14543"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000114"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0525-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.03.003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-941"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90370-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.11.020"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5145"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3023"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5219"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163949"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0789"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2696"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000207"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.218"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318182c2d2"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14410"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11808"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117135109"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.023"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0576-7"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06925-4"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.013"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000061"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju410"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2021-108269"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.5891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/path.5891","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.5891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:08:27Z","timestamp":1761052107000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.5891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/path.5891"],"URL":"https:\/\/doi.org\/10.1002\/path.5891","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,18]]},"assertion":[{"value":"2021-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}