{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:23:08Z","timestamp":1769912588866,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 2022 Annual Review Issue of <jats:italic>The Journal of Pathology<\/jats:italic>, Recent Advances in Pathology, contains 15 invited reviews on research areas of growing importance in pathology. This year, the articles include those that focus on digital pathology, employing modern imaging techniques and software to enable improved diagnostic and research applications to study human diseases. This subject area includes the ability to identify specific genetic alterations through the morphological changes they induce, as well as integrating digital and computational pathology with \u2018omics technologies. Other reviews in this issue include an updated evaluation of mutational patterns (mutation signatures) in cancer, the applications of lineage tracing in human tissues, and single cell sequencing technologies to uncover tumour evolution and tumour heterogeneity. The tissue microenvironment is covered in reviews specifically dealing with proteolytic control of epidermal differentiation, cancer\u2010associated fibroblasts, field cancerisation, and host factors that determine tumour immunity. All of the reviews contained in this issue are the work of invited experts selected to discuss the considerable recent progress in their respective fields and are freely available online (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/onlinelibrary.wiley.com\/journal\/10969896\">https:\/\/onlinelibrary.wiley.com\/journal\/10969896<\/jats:ext-link>). \u00a9 2022 The Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.5972","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T11:33:45Z","timestamp":1653910425000},"page":"379-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recent Advances in Pathology: the 2022 Annual Review Issue of <i>The Journal of Pathology<\/i>"],"prefix":"10.1002","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-8165","authenticated-orcid":false,"given":"C Simon","family":"Herrington","sequence":"first","affiliation":[{"name":"Edinburgh Cancer Research Centre, Institute of Genetics and Cancer University of Edinburgh  Edinburgh UK"},{"name":"Edinburgh Pathology Institute of Genetics and Cancer, University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-3543","authenticated-orcid":false,"given":"Richard","family":"Poulsom","sequence":"additional","affiliation":[{"name":"The Pathological Society of Great Britain and Ireland  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-4105","authenticated-orcid":false,"given":"Nischalan","family":"Pillay","sequence":"additional","affiliation":[{"name":"Sarcoma Biology and Genomics Group, UCL Cancer Institute  London UK"},{"name":"Department of Histopathology The Royal National Orthopaedic Hospital NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-8813","authenticated-orcid":false,"given":"Peter","family":"Bankhead","sequence":"additional","affiliation":[{"name":"Edinburgh Cancer Research Centre, Institute of Genetics and Cancer University of Edinburgh  Edinburgh UK"},{"name":"Edinburgh Pathology Institute of Genetics and Cancer, University of Edinburgh  Edinburgh UK"},{"name":"Centre for Genomic &amp; 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