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Macrophage migration inhibitory factor (MIF) is a pleiotropic molecule that plays a central role in various immune processes including the activation and proliferation of T cells; but whether MIF is intertwined in vitiligo development and progression and its involvement in aberrantly activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells remains ill\u2010defined. In this study, we found that MIF was overabundant in vitiligo patients and a mouse model for human vitiligo. Additionally, inhibiting MIF ameliorated the disease progression in vitiligo mice, which manifested as less infiltration of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and more retention of epidermal melanocytes in the tail skin. More importantly,\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments indicated that MIF\u2010inhibition suppressed the activation and proliferation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from the lymph nodes of vitiligo mice, and the effect extended to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in peripheral blood mononuclear cells of vitiligo patients. Finally, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells derived from MIF\u2010inhibited vitiligo mice also exhibited an impaired capacity for activation and proliferation. Taken together, our results show that MIF might be clinically targetable in vitiligo treatment, and its inhibition might ameliorate vitiligo progression by suppressing autoreactive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation and proliferation. \u00a9 2023 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.6073","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T08:44:09Z","timestamp":1677573849000},"page":"84-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<scp>MIF<\/scp>\n                    inhibition alleviates vitiligo progression by suppressing\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T cell activation and proliferation"],"prefix":"10.1002","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-5128","authenticated-orcid":false,"given":"Jianru","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-3898","authenticated-orcid":false,"given":"Weinan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-8259","authenticated-orcid":false,"given":"Pengran","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an PR 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