{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:37:49Z","timestamp":1782549469342,"version":"3.54.5"},"reference-count":95,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00130"],"award-info":[{"award-number":["PI17\/00130"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00375"],"award-info":[{"award-number":["PI20\/00375"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00487"],"award-info":[{"award-number":["PI20\/00487"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00140"],"award-info":[{"award-number":["PI20\/00140"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RICORS2040"],"award-info":[{"award-number":["RICORS2040"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0005\/0002"],"award-info":[{"award-number":["RD21\/0005\/0002"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["DTS19\/00093"],"award-info":[{"award-number":["DTS19\/00093"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012513","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013941","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015883","name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FJC2019\u2010042028\u2010I"],"award-info":[{"award-number":["FJC2019\u2010042028\u2010I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC\u20102017\u201022369"],"award-info":[{"award-number":["RYC\u20102017\u201022369"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravascular hemolysis is a common feature of different clinical entities, including sickle cell disease and malaria. Chronic hemolytic disorders are associated with hepatic damage; however, it is unknown whether heme disturbs lipid metabolism and promotes liver steatosis, thereby favoring the progression to nonalcoholic fatty liver disease (NAFLD). Using an experimental model of acute intravascular hemolysis, we report here the presence of liver injury in association with microvesicular lipid droplet deposition. Hemolysis promoted serum hyperlipidemia and altered intrahepatic triglyceride fatty acid composition, with increments in oleic, palmitoleic, and palmitic acids. These findings were related to augmented expression of transporters involved in fatty acid uptake (CD36 and MSR1) and deregulation of LDL transport, as demonstrated by decreased levels of LDL receptor and increased PCSK9 expression. Hemolysis also upregulated hepatic enzymes associated with cholesterol biosynthesis (SREBP2, HMGC1, LCAT, SOAT1) and transcription factors regulating lipid metabolism (SREBP1). Increased LC3II\/LC3I ratio and p62\/SQSTM1 protein levels were reported in mice with intravascular hemolysis and hepatocytes stimulated with heme, indicating a blockade of lipophagy. In cultured hepatocytes, cell pretreatment with the autophagy inductor rapamycin diminished heme\u2010mediated toxicity and accumulation of lipid droplets. In conclusion, intravascular hemolysis enhances liver damage by exacerbating lipid accumulation and blocking the lipophagy pathway, thereby promoting NAFLD. These new findings have a high translational potential as a novel NAFLD\u2010promoting mechanism in individuals suffering from severe hemolysis episodes. \u00a9 2023 The Authors. <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6161","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T04:47:03Z","timestamp":1691556423000},"page":"169-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intravascular hemolysis triggers <scp>NAFLD<\/scp> characterized by a deregulation of lipid metabolism and lipophagy blockade"],"prefix":"10.1002","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-2359","authenticated-orcid":false,"given":"Sandra","family":"Rayego\u2010Mateos","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biology in Renal and Vascular Pathology. IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz Universidad Aut\u00f3noma Madrid  Madrid Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Morgado\u2010Pascual","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  Cordoba Spain"},{"name":"Department of Cell Biology, Physiology and Immunology University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Garc\u00eda\u2010Caballero","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-9845","authenticated-orcid":false,"given":"Iolanda","family":"Lazaro","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Hospital del Mar Medical Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Sala\u2010Vila","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Hospital del Mar Medical Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Opazo\u2010Rios","sequence":"additional","affiliation":[{"name":"Health Science Faculty Universidad de Las Am\u00e9ricas  Concepci\u00f3n\u2010Talcahuano Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Mas\u2010Fontao","sequence":"additional","affiliation":[{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)  Madrid Spain"},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS)\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS)\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ruiz\u2010Ortega","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology in Renal and Vascular Pathology. IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz Universidad Aut\u00f3noma Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-2871","authenticated-orcid":false,"given":"Juan Antonio","family":"Moreno","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  Cordoba Spain"},{"name":"Department of Cell Biology, Physiology and Immunology University of Cordoba  Cordoba Spain"},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01970211"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08004.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2822"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809095200"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.03.025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00115.2002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1270"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v8.i3.108"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20198833"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814797116"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.08.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00500.2012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820974917"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14322"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105331"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073965"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2860-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2015.150202"},{"key":"e_1_2_8_20_1","first-page":"305","article-title":"Does serum lipid profile differ in anemia and non\u2010anemic older subjects?","volume":"8","author":"Shirvani M","year":"2017","journal-title":"Caspian J Intern Med"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2014.06.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.05.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.07.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.47.4.776"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000133"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.127498"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.53"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.35"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.185"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071813-105336"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.026"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.111075"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00740"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41345-8"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.52.35299"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.3.210"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410077200"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04575-z"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004812"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.341255"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0022-3565(24)37874-7","article-title":"Role of lipid peroxidation in dapsone\u2010induced hemolytic anemia","volume":"287","author":"McMillan DC","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(78)90332-7"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i44.9706"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9259"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1174-5"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.08.022"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.04.014"},{"key":"e_1_2_8_50_1","first-page":"663","article-title":"Serum lipids and atherogenic risk in sickle\u2010cell trait carriers","volume":"52","author":"Djoumessi S","year":"1994","journal-title":"Ann Biol Clin (Paris)"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933224"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.03.029"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70061-7"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.049"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24930"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23621"},{"key":"e_1_2_8_58_1","first-page":"351","article-title":"Re\u2010evaluation of fatty acid metabolism\u2010related gene expression in nonalcoholic fatty liver disease","volume":"20","author":"Kohjima M","year":"2007","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1993.11812816"},{"key":"e_1_2_8_60_1","first-page":"183","article-title":"Sickle\u2010cell anemia. The liver lesions. A clinical, morphological and ultrastructural study of 21 cases","volume":"46","author":"Hern\u00e1ndez C","year":"1992","journal-title":"G E N"},{"key":"e_1_2_8_61_1","first-page":"390","article-title":"Jaundice in Plasmodium falciparum","volume":"37","author":"Chawla LS","year":"1989","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_8_62_1","first-page":"1069","article-title":"Malarial hepatitis","volume":"51","author":"Kochar DK","year":"2003","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_8_63_1","first-page":"247","article-title":"Malarial hepatitis as a component of multiorgan failure\u2013a bad prognostic sign","volume":"105","author":"Das SN","year":"2007","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1179\/136485909X385054"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03761-1"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200131103018"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i46.7397"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10121-2"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12178"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.09.018"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161284298"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091892"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301189200"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.01.002"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.02.022"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008725200"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.42.29733"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0107-8"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380010602"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1983.63.4.1343"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.05.029"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.11.008"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00850"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1056"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.081232"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13071"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00584.2011"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358646"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1895658"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.02.015"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00407"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500002154"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf051468u"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:37:37Z","timestamp":1761057457000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/path.6161"],"URL":"https:\/\/doi.org\/10.1002\/path.6161","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"2022-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}