{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:57:13Z","timestamp":1771027033714,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2167"],"award-info":[{"award-number":["EXC 2167"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara\u00ae (imiquimod) cream results in psoriasiform dermatitis in mice. The Aldara\u00ae\u2010induced psoriasiform dermatitis (AIPD) mouse model has been used to examine the pathogenesis of psoriasis. Here, we used a forward genetics approach in which we compared AIPD that developed in 13 different inbred mouse strains to identify genes and pathways that modulated disease severity. Among our primary results, we found that the severity of AIPD differed substantially between different strains of inbred mice and that these variations were associated with polymorphisms in <jats:italic>Itga11<\/jats:italic>. The <jats:italic>Itga11<\/jats:italic> gene encodes the integrin \u03b111 subunit that heterodimerizes with the integrin \u03b21 subunit to form integrin \u03b111\u03b21. Less information is available about the function of ITGA11 in skin inflammation; however, a role in the regulation of cutaneous wound healing, specifically the development of dermal fibrosis, has been described. Experiments performed with <jats:italic>Itga11<\/jats:italic> gene\u2010deleted (<jats:italic>Itga11<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>) mice revealed that the integrin \u03b111 subunit contributes substantially to the clinical phenotype as well as the histopathological and molecular findings associated with skin inflammation characteristic of AIPD. Although the skin transcriptomes of <jats:italic>Itga11<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and WT mice do not differ from one another under physiological conditions, distinct transcriptomes emerge in these strains in response to the induction of AIPD. Most of the differentially expressed genes contributed to extracellular matrix organization, immune system, and metabolism of lipids pathways. Consistent with these findings, we detected a reduced number of fibroblasts and inflammatory cells, including macrophages, T cells, and tissue\u2010resident memory T cells in skin samples from <jats:italic>Itga11<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice in response to AIPD induction. Collectively, our results reveal that <jats:italic>Itga11<\/jats:italic> plays a critical role in promoting skin inflammation in AIPD and thus might be targeted for the development of novel therapeutics for psoriasiform skin conditions. \u00a9 2023 The Authors. <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6162","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T04:33:18Z","timestamp":1691728398000},"page":"184-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Forward genetics and functional analysis highlight <i>Itga11<\/i> as a modulator of murine psoriasiform dermatitis"],"prefix":"10.1002","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-6683","authenticated-orcid":false,"given":"Katja","family":"Bieber","sequence":"first","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-5267","authenticated-orcid":false,"given":"Siegfried","family":"Bezdek","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-4966","authenticated-orcid":false,"given":"Yask","family":"Gupta","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-0732","authenticated-orcid":false,"given":"Artem","family":"Vorobyev","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-8852","authenticated-orcid":false,"given":"Tanya","family":"Sezin","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-3285","authenticated-orcid":false,"given":"Natalie","family":"Gross","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-9629","authenticated-orcid":false,"given":"Jasper","family":"Pr\u00fcssmann","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Sayegh","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-824X","authenticated-orcid":false,"given":"Mareike","family":"Becker","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-2442","authenticated-orcid":false,"given":"Sadegh","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-9644","authenticated-orcid":false,"given":"Ashref","family":"Hdnah","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-5963","authenticated-orcid":false,"given":"Sven","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Max\u2010Planck Institute for Evolutionary Biology  Pl\u00f6n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-2290","authenticated-orcid":false,"given":"Saleh M","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"College of Medicine Khalifa University  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-1737","authenticated-orcid":false,"given":"Ralf J","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-4437","authenticated-orcid":false,"given":"Donald","family":"Gullberg","sequence":"additional","affiliation":[{"name":"University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-048X","authenticated-orcid":false,"given":"Christian D","family":"Sadik","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation of the Skin University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology, Allergy, and Venereology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15382"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806382"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31279-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00751.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018266"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2566"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343801"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13131"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0415-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402688"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11952-w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.01.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02262"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.548"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45614"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.01.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.438"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_862_15"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197228"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz401"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20486"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13886"},{"key":"e_1_2_8_28_1","article-title":"Integrated analysis of lncRNA and mRNA transcriptomes reveals new regulators of ubiquitination and the immune response in silica\u2010induced pulmonary fibrosis","volume":"2019","author":"Zhou Y","year":"2019","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09595-0_7"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0363"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-020-03300-y"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00041-07"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42274"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.24"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.025"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.11.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz046"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500551"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.9.2.225"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2852"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002343"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.12.003"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0556-6"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3192"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:37:39Z","timestamp":1761057459000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/path.6162"],"URL":"https:\/\/doi.org\/10.1002\/path.6162","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,11]]},"assertion":[{"value":"2022-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}