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However, the localization of club\u2010like cells in the human prostate, and their relationship to prostate cancer, is poorly understood. In a new article in <jats:italic>The Journal of Pathology<\/jats:italic>, RNA <jats:italic>in situ<\/jats:italic> hybridization was used to demonstrate that club cell markers are expressed in luminal cells adjacent to inflammation in the peripheral zone of the human prostate, where prostate cancer tends to arise. These club\u2010like cells are commonly found in proliferative inflammatory atrophy (PIA) lesions and express markers consistent with an intermediate epithelial cell\u2010type. Future studies will be needed to understand the functional role of club\u2010like cells in human prostate inflammation, regeneration, and disease. \u00a9 2023 The Authors. <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6213","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:58:53Z","timestamp":1696035533000},"page":"375-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prostatic proliferative inflammatory atrophy: welcome to the club<sup>\u2020<\/sup>"],"prefix":"10.1002","volume":"261","author":[{"given":"Matthew J","family":"Bernard","sequence":"first","affiliation":[{"name":"Molecular Biology Interdepartmental Program University of California, Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology University of California, Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-9149","authenticated-orcid":false,"given":"Andrew S","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology University of California, Los Angeles  Los Angeles CA USA"},{"name":"Department of Urology, David Geffen School of Medicine University of California, Los Angeles  Los Angeles CA USA"},{"name":"Jonsson Comprehensive Cancer Center University of California, Los Angeles  Los Angeles CA USA"},{"name":"Eli and Edythe Broad Stem Cell Research Center University of California, Los Angeles  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-1126"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018976118"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.086"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6149"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117679"},{"key":"e_1_2_4_7_1","first-page":"6182","article-title":"Colocalization of basal and luminal cell\u2010type cytokeratins in human prostate cancer","volume":"52","author":"Verhagen AP","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.010"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.584310"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00340-5"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.007"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6213","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:05:49Z","timestamp":1761044749000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/path.6213"],"URL":"https:\/\/doi.org\/10.1002\/path.6213","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}