{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:25:54Z","timestamp":1790886354434,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010441","name":"Medizinischen Fakult\u00e4t Heidelberg, Universit\u00e4t Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010441","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mesonephric\u2010like adenocarcinoma (MLA) of the female genital tract is an uncommon histotype that can arise in both the endometrium and the ovary. The exact cell of origin and histogenesis currently remain unknown. Here, we investigated whole genome DNA methylation patterns and copy number variations (CNVs) in a series of MLAs in the context of a large cohort of various gynaecological carcinoma types. CNV analysis of 19 MLAs uncovered gains of chromosomes 1q (18\/19, 95%), 10 (15\/19, 79%), 12 (14\/19, 74%), and 2 (10\/19, 53%), as well as loss of chromosome 1p (7\/19, 37%). Gains of chromosomes 1q, 10, and 12 were also identified in the majority of mesonephric adenocarcinomas of the uterine cervix (MAs) as well as subsets of endometrioid carcinomas (ECs) and low\u2010grade serous carcinomas of the ovary (LGSCs) but only in a minority of serous carcinomas of the uterine corpus (USCs), clear cell carcinomas (CCCs), and tubo\u2010ovarian high\u2010grade serous carcinomas (HGSCs). While losses of chromosome 1p together with gains of chromosome 1q were also identified in both MA and LGSC, gains of chromosome 2 were almost exclusively identified in MLA and MA. Unsupervised hierarchical clustering and t\u2010SNE analysis of DNA methylation data (Illumina EPIC array) identified a co\u2010clustering for MLAs and MAs, which was distinct from clusters of ECs, USCs, CCCs, LGSCs, and HGSCs. Group\u2010wise comparisons confirmed a close epigenetic relationship between MLA and MA. These findings, in conjunction with the established histological and immunophenotypical overlap, suggest bona fide mesonephric differentiation, and support a more precise terminology of mesonephric\u2010type adenocarcinoma instead of MLA in these tumours. \u00a9 2023 The Authors.\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.6217","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:14:50Z","timestamp":1697613290000},"page":"4-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mesonephric\u2010like adenocarcinoma harbours characteristic copy number variations and a distinct\n                    <scp>DNA<\/scp>\n                    methylation signature closely related to mesonephric adenocarcinoma of the cervix"],"prefix":"10.1002","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-9087","authenticated-orcid":false,"given":"Felix KF","family":"Kommoss","sequence":"first","affiliation":[{"name":"Department of Pathology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-3879","authenticated-orcid":false,"given":"Basile","family":"Tessier\u2010Cloutier","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-8250","authenticated-orcid":false,"given":"C Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin JR","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology King Edward Memorial Hospital  Subiaco WA Australia"},{"name":"School for Women's and Infants' Health University of Western Australia  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Heidelberg University Hospital and CCU Neuropathology DKFZ  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"K\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Classification of Tumours","author":"WHO Classification of Tumours Editorial 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ZapatkaM.conumee: enhanced copy\u2010number variation analysis using Illumina DNA methylation arrays R package version 1.9.0 2021. [Accessed 1 January 2021]. Available from:http:\/\/bioconductor.org\/packages\/conumee\/."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50267"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3252"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx513"},{"key":"e_1_2_7_28_1","unstructured":"KassambaraA.rstatix: Pipe\u2010Friendly Framework for Basic Statistical Tests R package version 0.7.0. 2021. [Accessed 1 January 2022]. Available from:https:\/\/CRAN.R-project.org\/package=rstatix."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01066-y"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3913"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0643-1"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:00:02Z","timestamp":1761066002000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/path.6217"],"URL":"https:\/\/doi.org\/10.1002\/path.6217","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"2023-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}