{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:26:00Z","timestamp":1790886360560,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesonephric adenocarcinomas (MAs) and mesonephric\u2010like adenocarcinomas (MLAs) are rare, aggressive neoplasms that arise in the gynecologic tract and show overlapping morphologic, immunohistochemical, and molecular features. While MAs occur in the cervix and are thought to arise from mesonephric remnants, MLAs occur in the endometrium and ovary and are believed to originate from transdifferentiation of M\u00fcllerian lesions. Both MAs and MLAs show a variety of architectural patterns, exhibit frequent expression of GATA3 by immunohistochemistry, and harbor <jats:italic>KRAS<\/jats:italic> mutations. In a recent article published in <jats:italic>The Journal of Pathology<\/jats:italic>, Kommoss and colleagues used DNA methylation profiling to extend these similarities and showed that MLAs and MAs cluster together based on their epigenetic signatures and are epigenetically distinct from other M\u00fcllerian adenocarcinomas. They also showed that MLAs and MAs harbor a high number of global copy number alterations. This study provides evidence that MLAs more closely resemble MAs than M\u00fcllerian carcinomas on an epigenetic level. As a result, the authors argue that MLA should be renamed \u2018mesonephric\u2010type adenocarcinoma.\u2019 Further research is needed to establish the relationship between these two entities, their etiology, and pathogenesis. \u00a9 2024 The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6285","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T14:57:57Z","timestamp":1712674677000},"page":"135-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From morphology to methylome: epigenetic studies of M\u00fcllerian mesonephric\u2010like adenocarcinoma reveal similarities to cervical mesonephric adenocarcinoma<sup>\u2020<\/sup>"],"prefix":"10.1002","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-9783","authenticated-orcid":false,"given":"Lawrence H","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-6680","authenticated-orcid":false,"given":"Brooke E","family":"Howitt","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Medical Center  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-6525","authenticated-orcid":false,"given":"David L","family":"Kolin","sequence":"additional","affiliation":[{"name":"Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.11.084"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000342"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12895"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001193"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6217"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14892"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13307"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.21873\/cgp.20235"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100321"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05070-z"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:11:48Z","timestamp":1761063108000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,9]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/path.6285"],"URL":"https:\/\/doi.org\/10.1002\/path.6285","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,9]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}