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This latter also exhibited gene\u2010based cell\u2013cell interactions suggestive of dynamic crosstalk between T<jats:sub>FH<\/jats:sub> and cancer cells in transcriptomics, further substantiated by using imaging mass cytometry. Our findings provide a comprehensive high\u2010resolution description of SMZL biological hallmarks and characterize, for the first time <jats:italic>in situ<\/jats:italic>, inter\u2010 and intra\u2010patient heterogeneity at both transcriptomic and protein levels. \u00a9 2024 The Authors. <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6296","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T04:16:28Z","timestamp":1717388188000},"page":"442-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integrated spatial and multimodal single\u2010cell transcriptomics reveal patient\u2010dependent cell heterogeneity in splenic marginal zone 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