{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:02Z","timestamp":1787235662096,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The histological similarities between pleomorphic adenomas (PAs) and cutaneous mixed tumors (CMTs) found in certain facial regions can create a diagnostic challenge. Molecular findings reveal common genetic profiles, particularly\n                    <jats:italic>PLAG1<\/jats:italic>\n                    rearrangements in both PA and CMT. Although molecular distinctions have received limited attention, our observations indicate multiple cases of CMTs carrying the\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    fusion. This clinical experience has driven our investigation into the potential diagnostic utility of\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    fusions for determining tumor origin. Two cohorts consisting of 46 cases of CMT and 45 cases of PA of the salivary glands were obtained from French institutions and reviewed by specialists in each subspecialty. RNA sequencing analysis was conducted to identify the molecular features of cases harboring\n                    <jats:italic>PLAG1<\/jats:italic>\n                    . Clinical, pathological, and molecular data were collected. In this study, cases of CMT exhibited recurrent gene fusions, primarily\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    (74%). These tumors shared characteristic histological features, including tubuloductal differentiation in 55% of cases and squamous metaplasia in varying proportions. In contrast, cases of PA had gene fusions involving\n                    <jats:italic>PLAG1<\/jats:italic>\n                    with various gene partners, with only one case in which\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    was identified. This disparity was also observed at the transcriptomic level between\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    CMTs and other tumors. However, TRPS1 immunostaining did not correlate with\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    fusion. In conclusion, we report that recurrent\n                    <jats:italic>TRPS1<\/jats:italic>\n                    ::\n                    <jats:italic>PLAG1<\/jats:italic>\n                    fusion CMTs exhibit similar characteristic histological features, including tubuloductal differentiation that is associated with squamous metaplasia in around half of cases. Detection of this fusion could be valuable in correctly identifying the origin of these tumors. \u00a9 2024 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.6359","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T04:29:59Z","timestamp":1730176199000},"page":"448-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the molecular landscape of cutaneous mixed tumors characterized by\n                    <scp>\n                      <i>TRPS1<\/i>\n                    <\/scp>\n                    ::\n                    <scp>\n                      <i>PLAG1<\/i>\n                    <\/scp>\n                    gene fusion"],"prefix":"10.1002","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-2836","authenticated-orcid":false,"given":"Ziyad","family":"Alsugair","sequence":"first","affiliation":[{"name":"Department of Pathology, Institute de Pathologie Multisite, Groupement Hospitalier Sud Lyon University Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Donzel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute de Pathologie Multisite, Groupement Hospitalier Sud Lyon University Hospital  Pierre\u2010B\u00e9nite France"},{"name":"University of Lyon, Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Macagno","sequence":"additional","affiliation":[{"name":"Department of Pathology Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet","family":"Tantot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute de Pathologie Multisite, Groupement Hospitalier Sud Lyon University Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Harou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute de Pathologie Multisite, Groupement Hospitalier Sud Lyon University Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-7431","authenticated-orcid":false,"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"Department of Pathology AP\u2010HP Hospital Saint\u2010Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sohier","sequence":"additional","affiliation":[{"name":"Department of Pathology, AP\u2010HP Cochin Hospital Centre\u2010Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Kervarrec","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e9 de Tours, Tours University Hospital  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"de la Fouchardi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Balme","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute de Pathologie Multisite, Groupement Hospitalier Sud Lyon University Hospital  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Champagnac","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Delphine","family":"Lanic","sequence":"additional","affiliation":[{"name":"INSERM U1245, Cancer Center Henri Becquerel, Institute of Research and Innovation in Biomedicine (IRIB) University of Normandy, UNIROUEN  Rouen France"},{"name":"Department of Pathology Cancer Center Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lopez","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department Groupement Hospitalier Sud  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marick","family":"La\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1245, Cancer Center Henri Becquerel, Institute of Research and Innovation in Biomedicine (IRIB) University of Normandy, UNIROUEN  Rouen France"},{"name":"Department of Pathology Cancer Center Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Descotes","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department Groupement Hospitalier Sud  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7817","authenticated-orcid":false,"given":"Franck","family":"Tirode","sequence":"additional","affiliation":[{"name":"Team Genetics, Epigenetics and Biology of Sarcomas Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052 \u2010 CNRS UMR5286, Centre L\u00e9on B\u00e9rard,Universit\u00e9 Claude Bernard Lyon 1  Lyon 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