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However, molecular studies have revealed a simpler and less controversial approach, categorizing these lesions into RAS\u2010like and BRAF p.V600E\u2010like neoplasms. In this review, the authors propose a classification that is based on, but does not require, the confirmation of molecular alterations. This approach aligns with and helps inform the pattern\u2010based assessment of tumor growth and cytologic atypia that is already widely used in clinical practice for preoperative patient stratification and tumor diagnosis, and promises a simpler conceptual understanding. \u00a9 2025 The Author(s). <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6456","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:19:24Z","timestamp":1754410764000},"page":"130-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Revisionist history uncovers a simplified molecular\u2010based classification of differentiated thyroid 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