{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:06:47Z","timestamp":1772626007082,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020349","name":"Fondazione Italiana per la ricerca sulle Malattie del Pancreas","doi-asserted-by":"publisher","award":["J38D19000690001"],"award-info":[{"award-number":["J38D19000690001"]}],"id":[{"id":"10.13039\/100020349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have attracted substantial attention since they represent the most prevalent macroscopic precursor of pancreatic cancer. Most lesions show an epithelium with low\u2010grade dysplasia and will remain indolent and unknown to the patient. Notably, a subgroup of IPMNs will progress to invasive cancer through a stepwise process characterized by the accumulation of specific genomic alterations and concomitant modifications of the tumor microenvironment (TME). The manuscript of Jamouss <jats:italic>et al<\/jats:italic>, recently published in <jats:italic>The Journal of Pathology<\/jats:italic>, expands the current knowledge on TME dynamics in IPMNs. The neoplastic progression of IPMNs is paralleled by a shift toward an immunosuppressive TME, with depletion of cytotoxic T cells, elevated expression of immune checkpoint molecules, including PD\u2010L1 and VISTA, and increased density of macrophages. Overall, TME modifications are crucial in the progression of pancreatic IPMNs, calling for potential therapeutic strategies focused on TME modulations for cancer interception. \u00a9 2025 The Author(s). <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6460","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:29:43Z","timestamp":1753882183000},"page":"126-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms<sup>\u2020<\/sup>"],"prefix":"10.1002","volume":"267","author":[{"given":"Antonio","family":"Pea","sequence":"first","affiliation":[{"name":"Department of General and Pancreatic Surgery \u2010 The Pancreas Institute Verona University Hospital Trust  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-4908","authenticated-orcid":false,"given":"Claudio","family":"Luchini","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Section of Pathology University of Verona  Verona Italy"},{"name":"ARC\u2010Net Research Center University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246188"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00235-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1955"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12157-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6402"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004427"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-2585"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15082326"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100223"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1588"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.6460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:38:02Z","timestamp":1758001082000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/path.6460"],"URL":"https:\/\/doi.org\/10.1002\/path.6460","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}