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Salivary gland basal cell tumours are uncommon and have not previously been reported in AFAP. We present a family with AFAP and multiple salivary gland tumours, including basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC). The colon and salivary gland tumours showed abnormal nuclear \u03b2\u2010catenin staining. Genomic analysis of both parotid BCACs showed copy\u2010number\u2010neutral loss of heterozygosity (CNN\u2010LOH) at the <jats:italic>APC<\/jats:italic> locus, implicating loss of full\u2010length APC in the aetiology of parotid BCACs. In contrast, the submandibular BCAC showed a p.(Ile35Thr) <jats:italic>CTNNB1<\/jats:italic> mutation. Spatial transcriptomic analysis revealed a stepwise increase in the expression of WNT pathway genes across the proband's salivary lesions, from benign (intercalated duct hyperplasia and BCAs) to malignant (BCACs). Our results showcase BCA and BCAC as potential new phenotypes of AFAP. \u00a9 2025 The Author(s). <jats:italic>The Journal of Pathology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.6466","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:46:21Z","timestamp":1755863181000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp><i>APC<\/i><\/scp>\u2010related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive <scp>WNT<\/scp> activation"],"prefix":"10.1002","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-1822","authenticated-orcid":false,"given":"Fiona","family":"Chan\u2010Pak\u2010Choon","sequence":"first","affiliation":[{"name":"Department of Human Genetics McGill University  Montreal QC 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