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To test this, we conducted an association study in a cohort of pregnant women from a malaria\u2010endemic region in northern Brazil, assessing whether specific functional single nucleotide variants (SNVs) in inflammasome genes affect (1) the response to <jats:italic>Plasmodium<\/jats:italic> infection and (2) the development of placental malaria. Our findings revealed that the <jats:italic>NLRP1<\/jats:italic> p.Met1154Val variant was associated with a protective effect against <jats:italic>Plasmodium<\/jats:italic> infection. Moreover, <jats:italic>IL1B<\/jats:italic> SNVs appeared more prevalent in severe cases. Additionally, multivariate analyses incorporating placental blood cytokines, growth factors, and immunohistochemical features revealed that the <jats:italic>NLRP1<\/jats:italic> p.Met1154Val variant correlated with a healthier placental state, highlighting a potential protective role of the NLRP1 inflammasome in GM. 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