{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:06:30Z","timestamp":1780596390894,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10430012010016"],"award-info":[{"award-number":["10430012010016"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Coronavirus disease 2019 (COVID\u201019) is of special concern to patients with chronic obstructive pulmonary disease (COPD), given their susceptibility to exacerbations caused by respiratory tract infections. As the susceptibility of acquiring a SARS\u2010CoV\u20102 infection in COPD remains unclear, this study explored the airway expression of SARS\u2010CoV\u20102 entry\u2010associated proteins in the lungs of COPD patients in comparison to non\u2010COPD controls. Immunohistochemical staining of lung tissue was performed to investigate the expression profiles of SARS\u2010CoV\u20102 entry\u2010associated proteins in the bronchial epithelium of 27 COPD patients and 40 non\u2010COPD controls. In addition, the associations between these expression profiles with lung function in COPD patients and smoking status in non\u2010COPD controls were examined. COPD patients demonstrated smoking\u2010independent lower expression of HSPA5, NRP1, BSG, TMPRSS2, and ITGB6 in airway epithelium as compared to non\u2010COPD controls. No significant differences were observed for Furin, CTSL, ADAM17, and ITGA5. BSG percentage area expression was significantly negatively associated with lung function in COPD patients. Moreover, the study revealed smoking\u2010associated differences for Furin, HSPA5, ADAM17, BSG, ITGA5, and ITGB6 within non\u2010COPD controls, with lower airway epithelial expression (except for Furin) in ever\u2010smokers than in never\u2010smokers. To conclude, this study showed a lower expression of a specific set of SARS\u2010CoV\u20102 entry\u2010associated proteins in the bronchial epithelium of COPD patients compared with non\u2010COPD controls, while other factors showed similar expression levels. The consequences of these findings on COVID\u201019 susceptibility remain uncertain. Although reduced expression of entry factors may suggest less cellular availability for viral entry, it could be speculated that the similar expression levels of other factors, together with impaired airway clearance in COPD, may still facilitate infection, thereby providing potential mechanistic insight into COVID\u201019 susceptibility in this patient population. \u00a9 2025 The Author(s).\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.6477","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:15:18Z","timestamp":1759742118000},"page":"424-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression of\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 entry\u2010associated proteins in\n                    <scp>COPD<\/scp>\n                    airways: an immunohistochemical study"],"prefix":"10.1002","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-0164","authenticated-orcid":false,"given":"Larissa E","family":"Vlaming\u2010van Eijk","sequence":"first","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarlasht","family":"Sarsam","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical 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