{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:14:21Z","timestamp":1769814861009,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["19\u2010CE14\u20100011\u201001"],"award-info":[{"award-number":["19\u2010CE14\u20100011\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202207610001"],"award-info":[{"award-number":["202207610001"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic kidney disease (CKD) is a major global health challenge affecting over 10% of the adult population. A hallmark of CKD progression is the transdifferentiation of kidney fibroblasts into extracellular matrix\u2010producing myofibroblasts, a key mechanism involved in the decline of kidney function and the development of kidney failure. Fibroblasts maintain the structural integrity of the kidney and support epithelial survival, repair, and regeneration after acute kidney injury. Maladaptive repair is a failure to resolve fibroblast activation, which ultimately progresses to chronic injury and CKD. In this study, we showed that the membrane\u2010bound coreceptor neuropilin 1 (NRP1) was essential to maintain fibroblast function and prevent their transdifferentiation into myofibroblasts. We used the myelin protein zero\u2010Cre (\n                    <jats:italic>P0\u2010Cre<\/jats:italic>\n                    ) to specifically abrogate\n                    <jats:italic>Nrp1<\/jats:italic>\n                    in kidney resident fibroblasts during fibrosis progression. We employed kidney\u2010induced interstitial fibrosis models combined with a lineage\u2010tracing strategy, single\u2010cell RNA sequencing analysis, and\n                    <jats:italic>ex vivo<\/jats:italic>\n                    explant cultures to reveal a cell autonomous protective role for NRP1 in limiting fibrosis. Furthermore, we extended the analysis by showing that\n                    <jats:italic>Nrp1<\/jats:italic>\n                    conditional mutants were more prone to develop cardiac fibrosis in a mouse model of heart failure. Collectively, these findings provide new insights into the signalling pathways controlling the transition from acute to chronic kidney disease conversion and identify NRP1 as a novel regulator of fibroblast supportive function. \u00a9 2025 The Author(s).\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70009","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:29:07Z","timestamp":1766492947000},"page":"127-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibroblast\u2010derived neuropilin 1 alleviates renal fibrosis progression"],"prefix":"10.1002","volume":"268","author":[{"given":"Yunzhu","family":"Shen","sequence":"first","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Placier","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane","family":"Louedec","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrine","family":"Fr\u00e8re","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Vandermeersch","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-9163","authenticated-orcid":false,"given":"Stefanny","family":"Figueroa","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos E","family":"Chadjichristos","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Cohen","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie H\u00e9modialyse, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9, Centre de recherche sur l'inflammation, INSERM U1149, H\u00f4pital Bichat \u2010 Claude Bernard  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Chatziantoniou","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-6153","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Calmont","sequence":"additional","affiliation":[{"name":"INSERM U1155, H\u00f4pital Tenon Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM U942 MASCOT Universit\u00e9 Paris Cit\u00e9  Paris 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