{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:25:21Z","timestamp":1784777121639,"version":"3.55.0"},"reference-count":140,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water\u2010holding functions and in initiating AD\u2010like skin symptoms and disease\u2010specific molecular alterations, we generated Tg mice overexpressing a mutant form of acid ceramidase (aCDase) under the control of the involucrin promoter, resulting in targeted expression in the upper epidermis. By 3\u2009weeks of age, Tg mice developed noninflammatory, scaly skin characterized by severely compromised barrier integrity and water\u2010holding capacity, along with significantly elevated epidermal aCDase activity and markedly reduced ceramide levels in the SC. Compared to WT controls, Tg mice also exhibited increased epidermal innervation and reduced intraepidermal semaphorin 3a protein levels. Additionally, Tg skin showed substantial changes in the expression of AD\u2010associated biomarkers involved in barrier impairment, pruritus, and Th2 polarization. These included increased levels of\n                    <jats:italic>Il10<\/jats:italic>\n                    ,\n                    <jats:italic>Il17a<\/jats:italic>\n                    ,\n                    <jats:italic>S100a7<\/jats:italic>\n                    ,\n                    <jats:italic>S100a8<\/jats:italic>\n                    , and\n                    <jats:italic>S100a9<\/jats:italic>\n                    and decreased levels of\n                    <jats:italic>Cxcl10<\/jats:italic>\n                    ,\n                    <jats:italic>Ifng, Il2<\/jats:italic>\n                    ,\n                    <jats:italic>Il13<\/jats:italic>\n                    ,\n                    <jats:italic>Il33<\/jats:italic>\n                    ,\n                    <jats:italic>Sema3a<\/jats:italic>\n                    ,\n                    <jats:italic>and Tlr<\/jats:italic>\n                    9. Repeated topical application of mite antigens induced allergic responses in Tg mice, but not in WT mice. These responses were characterized by prominent eosinophil infiltration in the dermis and significantly elevated serum IgE levels. Allergen\u2010challenged ear skin from Tg mice also demonstrated significantly increased expression of inflammatory mediators related to AD, including\n                    <jats:italic>Ccl17<\/jats:italic>\n                    ,\n                    <jats:italic>Ccl22<\/jats:italic>\n                    ,\n                    <jats:italic>Ccl26<\/jats:italic>\n                    ,\n                    <jats:italic>Ccl27<\/jats:italic>\n                    ,\n                    <jats:italic>Il3<\/jats:italic>\n                    ,\n                    <jats:italic>Il13<\/jats:italic>\n                    ,\n                    <jats:italic>Il22<\/jats:italic>\n                    , and\n                    <jats:italic>Il33<\/jats:italic>\n                    . These findings establish Tg mice as a pathophysiologically relevant model of AD, presenting key features such as xerotic, pruritic skin, impaired barrier and water\u2010retention functions, and Th2\u2010dominant allergic inflammation. This model provides important insights into ceramide\u2010dependent mechanisms in AD pathogenesis and offers a useful platform for therapeutic development. \u00a9 2026 The Author(s).\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70050","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:38:02Z","timestamp":1774341482000},"page":"232-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2\u2010skewed immune polarization"],"prefix":"10.1002","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2469-0047","authenticated-orcid":false,"given":"Mariko","family":"Takada","sequence":"first","affiliation":[{"name":"Center for Bioscience Research and Education Utsunomiya University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0208-3374","authenticated-orcid":false,"given":"Miho","family":"Sashikawa\u2010Kimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-1043","authenticated-orcid":false,"given":"Yusuke","family":"Ohno","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Juntendo University  Chiba Japan"},{"name":"Institute for Environmental and Gender\u2010Specific Medicine, Juntendo University Graduate School of Medicine  Chiba Japan"},{"name":"Advanced Research Center for Health Drug Discovery, Juntendo University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5844-0941","authenticated-orcid":false,"given":"Md Razib","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-7240","authenticated-orcid":false,"given":"Xiaonan","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Bioscience Research and Education Utsunomiya University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-4206","authenticated-orcid":false,"given":"Kazuhisa","family":"Iwabuchi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Juntendo University  Chiba Japan"},{"name":"Institute for Environmental and Gender\u2010Specific Medicine, Juntendo University Graduate School of Medicine  Chiba Japan"},{"name":"Advanced Research Center for Health Drug Discovery, Juntendo University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-1803","authenticated-orcid":false,"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-6698","authenticated-orcid":false,"given":"Mamitaro","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-4475","authenticated-orcid":false,"given":"Genji","family":"Imokawa","sequence":"additional","affiliation":[{"name":"Center for Bioscience Research and Education Utsunomiya University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041613"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000036874.83540.2B"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091909"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470233"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01846.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015559850135788"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000059931.66821.92"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.161"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02326.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200225-JLR200"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1430-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506040-00002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.034"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12265365"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41978-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115439"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116374"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117160"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39184-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.175"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.01.014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1743"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700459"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2020"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.29"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.046"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10475.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.277"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01449.x"},{"key":"e_1_2_9_32_1","first-page":"111","article-title":"Senile xerosis: functional, morphological, and biochemical studies","volume":"1","author":"Hara M","year":"1993","journal-title":"J Geriatr Dermatol"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.068"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00191.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.01.013"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00192-13"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.3.120"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.02.006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr494"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2022.105255"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13497"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9554.1000206"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3500747"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12348937"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00072.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228789"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168737"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709166200"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03844-2"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90211-2"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA120000671"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<769::AID-IMMU769>3.0.CO;2-H"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38401-7"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.046"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.4.1956"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.029"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18246"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13203167"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.268"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.09.005"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.09-0423"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.617"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12563"},{"key":"e_1_2_9_65_1","first-page":"2476","article-title":"Effect of S100A8 and S100A9 on expressions of cytokine and skin barrier protein in human keratinocytes","volume":"20","author":"Kim MJ","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090472"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.012"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041314"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/315672a0"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb08098.x"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1159\/000234661"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn037"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.03.007"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12317"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08410.x"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1950"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S94056"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.12.022"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.029"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021585"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.223784"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.04.007"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.01.057"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000199714"},{"key":"e_1_2_9_86_1","first-page":"389","article-title":"Translational animal models of atopic dermatitis for preclinical studies","volume":"90","author":"Martel BC","year":"2017","journal-title":"Yale J Biol Med"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371746"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155598441783"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00668.x"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00406688"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(93)90767-J"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90486-7"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91556-1"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690110059007"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb01847.x"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.271"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555566404408"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb02167.x"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106484"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70024-2"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.007"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02430.x"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00851.x"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01225.x"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03634.x"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1198-9"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/138027"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01727.x"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126079"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00774.x"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00692.x"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01285.x"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12440"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.031"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12431"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12830"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00630"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_9_119_1","first-page":"240","article-title":"Reduction of serum TARC levels in atopic dermatitis by topical anti\u2010inflammatory treatments","volume":"32","author":"Yasukochi Y","year":"2014","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.06.001"},{"key":"e_1_2_9_121_1","first-page":"9","article-title":"Serum thymus and activation regulated chemokine (TARC), IL\u2010 18 and IL\u201018 gene polymorphism as associative factors with atopic dermatitis","volume":"24","author":"Gohar MK","year":"2017","journal-title":"Egypt J Immunol"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12992"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.00052.x"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1723"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07201.x"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.09.001"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.2983"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.015"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.02.016"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.041"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-005-0068-y"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.013"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01501.x"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.042"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.037"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.08.024"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1996.0184"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13160"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.07.013"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.05.066"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.041"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.70050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:14:12Z","timestamp":1778832852000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.70050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":140,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/path.70050"],"URL":"https:\/\/doi.org\/10.1002\/path.70050","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}