{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:01:44Z","timestamp":1780617704790,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["PX2023029"],"award-info":[{"award-number":["PX2023029"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multinodular and vacuolating neuronal tumor (MVNT) was recognized as a distinct neuronal tumor entity in the revision of the 2021 World Health Organization (WHO) Classification of Tumors of the CNS. In this study, we retrospectively analyzed 12 surgical cases, two of which exhibited ganglioglioma (GG)\u2010like components. The cohort consisted of eight male and four female patients, with a median age of 31\u2009years (age range: 18\u201353\u2009years). Seizures were the most common clinical presentation, followed by headache and dizziness. Three patients were incidentally identified during physical examination. Ten tumors were located in the cerebral hemisphere, and the remaining two were found in the cerebellum and thalamus, respectively. Histopathological examination revealed clusters of neuroepithelial cells with large amphophilic vacuolated cytoplasm and eccentrically placed round nuclei containing prominent nucleoli. Immunohistochemically, these vacuolated cells were positive for OLIG2, MAP2, SYN and SOX10, and negative for GFAP and NEUN. DNA sequencing analysis identified no mutations in\n                    <jats:italic>IDH1<\/jats:italic>\n                    ,\n                    <jats:italic>IDH2<\/jats:italic>\n                    ,\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600E,\n                    <jats:italic>TERT<\/jats:italic>\n                    promoter, or\n                    <jats:italic>EGFR<\/jats:italic>\n                    genes. Among the cohort, three cases harbored\n                    <jats:italic>FGFR2<\/jats:italic>\n                    mutations, and\n                    <jats:italic>FGFR2<\/jats:italic>\n                    ::\n                    <jats:italic>INA<\/jats:italic>\n                    gene fusion was detected in both MVNT and GG\u2010like components. Two cases carried\n                    <jats:italic>BRAF<\/jats:italic>\n                    mutation, and one case exhibited\n                    <jats:italic>MAP2K1<\/jats:italic>\n                    mutation. A novel\n                    <jats:italic>BCAN::NTRK1<\/jats:italic>\n                    (exon 12\u2013exon 9) gene fusion was identified in one case. DNA methylation profiling of eight cases revealed that none matched with a known CNS tumor type. Six cases formed a separate methylation cluster, suggesting a potential novel molecular subtype, while the remaining two cases exhibited transcriptional similarities to supratentorial pilocytic astrocytoma and rosette\u2010forming glioneuronal tumor (RGNT), respectively. Postoperatively, all patients remained seizure free with no evidence of tumor progression. Only one patient died 16\u2009months after surgery due to an unrelated traffic accident. \u00a9 2026 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70056","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:05:19Z","timestamp":1774436719000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multinodular and vacuolating neuronal tumor: molecular genetics and\n                    <scp>DNA<\/scp>\n                    methylation analysis of 12 cases"],"prefix":"10.1002","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0180-262X","authenticated-orcid":false,"given":"Fang","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing Geriatric Medical Research Center  Beijing PR China"},{"name":"Department of Clinical Laboratory, Tsinghua University Hospital Tsinghua University  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9665-3729","authenticated-orcid":false,"given":"Dan\u2010Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing Geriatric Medical Research Center  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5951-7477","authenticated-orcid":false,"given":"Jing","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-6587","authenticated-orcid":false,"given":"Tao","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University Army Medical University  Chongqing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Ai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing Geriatric Medical Research Center  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing Geriatric Medical Research Center  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-0723","authenticated-orcid":false,"given":"Ni","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu PR 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