{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:47:14Z","timestamp":1787784434492,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"4-5","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2019\/SKK08\/UM\/02\/6"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK08\/UM\/02\/6"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007110","name":"Akademi Sains Malaysia","doi-asserted-by":"publisher","award":["MR\/P013201\/1 (IF016\u20102017)"],"award-info":[{"award-number":["MR\/P013201\/1 (IF016\u20102017)"]}],"id":[{"id":"10.13039\/501100007110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010143","name":"Facolt\u00e0 di Medicina e Psicologiaa, Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["YOURII MSCA2024\u2010000104"],"award-info":[{"award-number":["YOURII MSCA2024\u2010000104"]}],"id":[{"id":"10.13039\/100010143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    It is widely recognized that latent infection is the predominant mode of Epstein\u2013Barr virus (EBV) infection in nasopharyngeal carcinoma (NPC) in which a specific set of latent genes is responsible for driving the development of the disease. However, the expression of these latent genes does not adequately explain the various transformed phenotypes of NPC cells. Using an established high\u2010throughput quantitative reverse transcription PCR array, we found that several EBV lytic genes were more widely expressed in primary NPC tissues than previously recognized. We focused on a lytic gene,\n                    <jats:italic>BILF1<\/jats:italic>\n                    , which encodes a constitutively active G protein\u2010coupled receptor (GPCR). We showed that\n                    <jats:italic>BILF1<\/jats:italic>\n                    was expressed in tumour cells from primary NPC tissues at both mRNA and protein levels, and in the absence of\n                    <jats:italic>BZLF1<\/jats:italic>\n                    expression. RNA sequencing analysis of\n                    <jats:italic>BILF1<\/jats:italic>\n                    \u2010expressing immortalised nasopharyngeal epithelial (NPE) cells demonstrated that the profile of BILF1\u2010regulated genes significantly overlapped with gene signatures of micro\u2010dissected NPC, indicating that the expression of BILF1 is relevant to the pathogenesis of NPC. In accordance with these observations, pathway analysis of the transcriptome of\n                    <jats:italic>BILF1<\/jats:italic>\n                    \u2010expressing cells showed the involvement of BILF1 in key biological processes typically deregulated in NPC. To examine whether BILF1 expression influenced epithelial cell behaviour, functional studies showed that BILF1 enhanced cell proliferation, migration, invasion and colony formation. In addition, BILF1 increased AKT activation in NPE cells, which was responsible for the increase in cell migration. Taken together, our data convincingly point to an oncogenic role for BILF1 in NPC. \u00a9 2026 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70069","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:30:32Z","timestamp":1778218232000},"page":"412-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An oncogenic role for\n                    <scp>EBV<\/scp>\n                    \u2010encoded\n                    <scp>BILF1<\/scp>\n                    in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"269","author":[{"given":"Anna KC","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Oral and Craniofacial Sciences and Oral Cancer Research &amp; Coordinating Centre, Faculty of Dentistry Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinotheni","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences and Oral Cancer Research &amp; Coordinating Centre, Faculty of Dentistry Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Mundo","sequence":"additional","affiliation":[{"name":"Medical Biotechnology University of Siena  Siena Italy"},{"name":"Limerick Digital Cancer Research Centre, School of Medicine, Bernal Institute, and Health Research Institute University of Limerick  Limerick Ireland"},{"name":"Clinical and Molecular Medicine Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-6999","authenticated-orcid":false,"given":"Wenbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biosciences Durham University  Durham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew I","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Cancer and Genomic Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-6865","authenticated-orcid":false,"given":"Max","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Newcastle Upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Bellan","sequence":"additional","affiliation":[{"name":"Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Lazzi","sequence":"additional","affiliation":[{"name":"Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara","family":"Leahy","sequence":"additional","affiliation":[{"name":"Limerick Digital Cancer Research Centre, School of Medicine, Bernal Institute, and Health Research Institute University of Limerick  Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathmanathan","family":"Rajadurai","sequence":"additional","affiliation":[{"name":"Subang Jaya Medical Centre  Subang Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew Toong","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanan","family":"Prepageran","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S","family":"Young","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-6124","authenticated-orcid":false,"given":"Kwok\u2010Wai","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G","family":"Murray","sequence":"additional","affiliation":[{"name":"Limerick Digital Cancer Research Centre, School of Medicine, Bernal Institute, and Health Research Institute University of Limerick  Limerick Ireland"},{"name":"Department of Pathology, School of Medicine Royal College of Surgeons Ireland  Manama Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-401X","authenticated-orcid":false,"given":"Ian C","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences and Oral Cancer Research &amp; Coordinating Centre, Faculty of Dentistry Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-3607","authenticated-orcid":false,"given":"Lee Fah","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences and Oral Cancer Research &amp; Coordinating Centre, Faculty of Dentistry Universiti Malaya  Kuala Lumpur Malaysia"},{"name":"University Malaya Cancer Research Institute Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602449"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00055-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00600"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.84"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14235780"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.10.030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.536-546.2005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.441-449.2005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.173"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2020.1777525"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000255"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01608-10"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r29"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.3.872.872"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4399"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041055"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-022-00397-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24348-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102462"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005158"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01239-17"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-016-0436-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02380-13"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00402-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01110-15"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01790-12"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.12.9858-9866.1999"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4879"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63150-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4460"},{"key":"e_1_2_8_33_1","first-page":"553","article-title":"Immunoreactivity of ICAM\u20101 in human tumors, metastases and normal tissues","volume":"2","author":"Hayes SH","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00223-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.02.034"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002448200"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.70069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:31:13Z","timestamp":1783474273000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.70069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":35,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/path.70069"],"URL":"https:\/\/doi.org\/10.1002\/path.70069","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}