{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:40:03Z","timestamp":1783968003478,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4-5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Canalicular adenoma (CA) is a benign salivary gland tumor predominantly affecting the upper lip and is characterized by monomorphic epithelial cells arranged in branching cords within a loose and vascularized stroma. Unlike pleomorphic adenoma (PA), CA lacks a chondroid matrix and exhibits specific histological features, such as high cuboidal to columnar cells arranged in one to two cell layers. A recently identified PA subtype, named \u2018\n                    <jats:italic>HMGA2<\/jats:italic>\n                    \u2010canalicular\u2010like PA\u2019, mimics the morphology of CA but affects major salivary glands, and harbors the\n                    <jats:italic>HMGA2<\/jats:italic>\n                    ::\n                    <jats:italic>WIF1<\/jats:italic>\n                    fusion. Immunohistochemical markers including SOX10 positivity and p40\/p63 negativity are shared between these entities, raising questions about their molecular differences. Therefore, the current study aimed to extensively compare the molecular profiles of CAs and\n                    <jats:italic>HMGA2<\/jats:italic>\n                    \u2010canalicular\u2010like PAs to better understand the mechanisms underlying their oncogenesis. In the present study, CAs and the\n                    <jats:italic>HMGA2<\/jats:italic>\n                    \u2010canalicular\u2010like PAs mostly shared similar histology and immunostaining, while the clinical presentations regarding tumor site and transcriptomic profiles were different. A novel finding was the overexpression of SOX2 in patients diagnosed with CA, in comparison to those diagnosed with\n                    <jats:italic>HMGA2<\/jats:italic>\n                    \u2010canalicular\u2010like PA. The CAs displayed significantly higher enrichment of hallmarks for Hedgehog signaling, IL2\/STAT5 signaling, and apical surface, and significantly lower enrichment of hallmarks for apoptosis and mitotic spindle. Additionally, Gene Ontology enrichment analysis displayed significant enrichment of biological process for CAs in comparison to\n                    <jats:italic>HMGA2<\/jats:italic>\n                    \u2010canalicular\u2010like PAs for myofibril assembly, muscle filament sliding, actin\u2013myosin filament sliding, and sarcomere organization. CAs and\n                    <jats:italic>HMGA2<\/jats:italic>\n                    \u2010canalicular\u2010like PAs exhibited similar histology and immunostaining but differed significantly in tumor site and transcriptomic profiles. The latter revealed significant activation of muscle\u2010related transcriptional pathways, and overexpression of SOX2 in CAs. \u00a9 2026 The Author(s).\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70070","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:46:19Z","timestamp":1777455979000},"page":"423-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptomic comparative study between canalicular adenoma and\n                    <scp>\n                      <i>HMGA2<\/i>\n                    <\/scp>\n                    ::\n                    <scp>\n                      <i>WIF1<\/i>\n                    <\/scp>\n                    canalicular\u2010like pleomorphic adenoma"],"prefix":"10.1002","volume":"269","author":[{"given":"Ziyad","family":"Alsugair","sequence":"first","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologiques, Institut de Pathologie Multisite, Hospices Civils de Lyon, CHU Lyon Sud  Pierre\u2010B\u00e9nite France"},{"name":"D\u00e9partement de Biopathologie Centre Leon Berard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Champagnac","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biopathologie Centre Leon Berard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-2286","authenticated-orcid":false,"given":"Maxime","family":"Fieux","sequence":"additional","affiliation":[{"name":"Service of Oto\u2010Rhino\u2010Laryngology, CHU Sud, Hospices Civils de Lyon  Pierre B\u00e9nite France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1  Lyon 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