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Anti\u2010vascular endothelial growth factor agents are commonly used to treat this condition, yet their variable efficacy and off\u2010target effects demand alternative strategies. Here, we investigated the relationship between retinal dopamine (DA) dynamics and pathological angiogenesis in the oxygen\u2010induced retinopathy (OIR) mouse model mimicking ROP pathogenesis. We determined the individual effects of apomorphine (APO), a non\u2010selective DA receptor agonist, and selective agonists or antagonists of dopamine D1 receptor (Drd1) and dopamine D2 receptor (Drd2), on pathological neovascularization. Integrating single\u2010cell RNA sequencing with M\u00fcller cell\u2010specific\n                    <jats:italic>Drd2<\/jats:italic>\n                    knockout OIR mice, we identified that Drd2\u2010mediated signaling in M\u00fcller cells orchestrates hypoxia\u2010inducible factor alpha and vascular endothelial growth factor A biosynthesis in M\u00fcller cells during the hypoxic\u2013ischemic phase of OIR. Collectively, OIR\u2010induced dopaminergic deficiency and impaired Drd2 activity in M\u00fcller cells synergistically exacerbate pathological angiogenesis. \u00a9 2026 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70080","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:45:17Z","timestamp":1780544717000},"page":"40-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dopamine inhibits retinal pathological neovascularization in the oxygen\u2010induced retinopathy mouse model"],"prefix":"10.1002","volume":"270","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital Wenzhou Medical University  Zhejiang PR China"},{"name":"Research Unit of Myopia Basic Research and 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