{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:18Z","timestamp":1785772458964,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The axillary lymph node remains a cornerstone of breast cancer staging and therapeutic decision\u2010making, yet it is still largely interpreted through a static anatomical framework. Emerging evidence challenges this paradigm, positioning tumor\u2010draining lymph nodes as dynamic immunological ecosystems that actively regulate tumor progression and host response. In this context, Llewellyn\n                    <jats:italic>et al<\/jats:italic>\n                    introduce a quantitative framework to characterize fibroblastic reticular cell network topology and link nodal architecture to clinical outcomes. By quantifying features such as lacunarity, branching, and alignment in a breast cancer cohort, the authors show that fibroblastic reticular cell network organization is associated with prognosis in a context\u2010dependent manner. While this approach represents a significant conceptual and methodological advance, its biological interpretation remains limited by the absence of functional validation and integrated immune profiling. Accumulating evidence indicates that lymph node microenvironments undergo profound immune reprogramming, highlighting the close interdependence between stromal topology and immune composition. These findings suggest that structural features alone may reflect distinct underlying biological states. Integrating spatial metrics with immune characterization may refine current staging systems, improve risk stratification, and ultimately inform future evolution of staging classifications by incorporating functional and spatial dimensions of nodal involvement. \u00a9 2026 The Author(s).\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70085","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:15:51Z","timestamp":1779880551000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymph node stromal topology as a hidden regulator of breast cancer outcome: commentary on reticular network analysis\n                    <sup>\u2020<\/sup>"],"prefix":"10.1002","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-0892","authenticated-orcid":false,"given":"Andrea","family":"Vethencourt","sequence":"first","affiliation":[{"name":"Institut Catal\u00e0 d'Oncologia, Medical Oncology Department Breast Cancer Unit  Barcelona Spain"},{"name":"IDIBELL, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-3801","authenticated-orcid":false,"given":"Roberto","family":"Salgado","sequence":"additional","affiliation":[{"name":"Department of Pathology ZAS Hospitals  Antwerp Belgium"},{"name":"Division of Research Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-8171","authenticated-orcid":false,"given":"Eva","family":"Gonzalez\u2010Suarez","sequence":"additional","affiliation":[{"name":"IDIBELL, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge  Barcelona Spain"},{"name":"Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_4_3_1","unstructured":"Breast Cancer \u2010 Guidelines Detail [Internet]. [cited 2026 Mar 30] Available from:https:\/\/www.nccn.org\/guidelines\/guidelines-detail?id=1419."},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01565"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11470"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2412063"},{"key":"e_1_2_4_7_1","article-title":"Axillary treatment for operable primary breast cancer","volume":"1","author":"Bromham N","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.05.006"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64981-z"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.70065"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.08.015"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34581-2"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52577-y"},{"key":"e_1_2_4_14_1","unstructured":"TADPOLE|Association of Breast Surgery [Internet]. [cited 2026 Apr 27] Available from:https:\/\/associationofbreastsurgery.org.uk\/professionals\/research\/trials\/open-recruiting\/tadpole."},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188704"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104745"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.016"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409932"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.70085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:05:25Z","timestamp":1785769525000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.70085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/path.70085"],"URL":"https:\/\/doi.org\/10.1002\/path.70085","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}