{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:53:41Z","timestamp":1789487621379,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Colon cancer progression is closely associated with the tumor microenvironment, where cancer\u2010associated fibroblasts (CAFs) play a pivotal role. Exosomal long non\u2010coding RNAs (lncRNAs) are known to modulate the tumor stroma, but the role of lncRNA\n                    <jats:italic>PVT1<\/jats:italic>\n                    (plasmacytoma variant translocation 1) in exosome\u2010mediated fibroblast activation in colon cancer remains poorly understood. This study demonstrated significantly elevated\n                    <jats:italic>PVT1<\/jats:italic>\n                    levels in colon cancer tissues. Mechanistically, hypoxia\/reoxygenation (H\/R) induced the recruitment of HIF\u20101\u03b1 to the\n                    <jats:italic>PVT1<\/jats:italic>\n                    promoter, directly activating its transcription and subsequent exosomal loading. Exosomes derived from H\/R\u2010treated colon cancer cells promoted fibroblast activation into a CAF phenotype.\n                    <jats:italic>PVT1<\/jats:italic>\n                    was found to sponge miR\u201023b\u20105p, thereby upregulating a network of target genes. Importantly, silencing of\n                    <jats:italic>MAPK13<\/jats:italic>\n                    , a key downstream target, significantly abrogated the\n                    <jats:italic>PVT1<\/jats:italic>\n                    \u2010mediated fibroblast\u2010to\u2010CAF transformation.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments confirmed that exosomal\n                    <jats:italic>PVT1<\/jats:italic>\n                    enhanced CAF infiltration and tumor growth, whereas these effects were reversed by either restoring miR\u201023b\u20105p expression or knocking out\n                    <jats:italic>PVT1<\/jats:italic>\n                    . These findings uncover a novel mechanism whereby H\/R\u2010induced exosomal\n                    <jats:italic>PVT1<\/jats:italic>\n                    promotes fibroblast activation and CAF transformation via the miR\u201023b\u20105p signaling axis, providing potential diagnostic biomarkers and therapeutic targets for modulating the tumor stroma in colon cancer. \u00a9 2026 The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70098","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:18:30Z","timestamp":1785489510000},"page":"255-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosomal\n                    <scp>\n                      lncRNA\n                      <i>PVT1<\/i>\n                    <\/scp>\n                    promotes fibroblast activation and colon cancer progression via\n                    <scp>miR<\/scp>\n                    \u201023b\u20105p signaling"],"prefix":"10.1002","volume":"270","author":[{"given":"Liuping","family":"You","sequence":"first","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5911-335X","authenticated-orcid":false,"given":"Yuenan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Harbin Medical University  Harbin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310912"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_9_5_1","first-page":"582","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri R","year":"2016","journal-title":"Nat Rev Genet"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.034"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2010.06.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32762"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9055-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1089-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2015.10"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02488-x"},{"key":"e_1_2_9_13_1","first-page":"1261","article-title":"Regulation of lncRNA PVT1 on miR\u2010125 in metastasis of gastric cancer cells","volume":"19","author":"Niu JT","year":"2020","journal-title":"Oncol Lett"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9959807"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317699122"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2023_221208N1169"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.03.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13400"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05328-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13311"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01287-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28377"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14762"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgy006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203481"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00393-1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237-025-00548-z"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00440-0"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28077"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05541-x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjab042"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0381-y"},{"key":"e_1_2_9_35_1","article-title":"Cancer\u2010associated fibroblast\u2010derived extracellular vesicles: regulators and therapeutic targets in the tumor microenvironment","volume":"8","author":"Xie JD","year":"2025","journal-title":"Cancer Drug Resist"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03432-5"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/path.70098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.70098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:32:18Z","timestamp":1789482738000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.70098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/path.70098"],"URL":"https:\/\/doi.org\/10.1002\/path.70098","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}