{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:11:25Z","timestamp":1789031485118,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA058236"],"award-info":[{"award-number":["P50CA058236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA196390"],"award-info":[{"award-number":["U01CA196390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA247886"],"award-info":[{"award-number":["P01CA247886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54CA274370"],"award-info":[{"award-number":["U54CA274370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA180995"],"award-info":[{"award-number":["P50CA180995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The cellular composition and disease susceptibilities of the distinct zones of the human prostate remain incompletely understood. Benign prostatic hyperplasia (BPH) is a common condition that causes widespread morbidity and is nearly exclusively localized to the transition zone (TZ). Through extensive single\u2010cell RNA sequencing (scRNA\u2010seq) of benign regions from prostatectomy specimens, we identified a basal cell population expressing\n                    <jats:italic>WIF1<\/jats:italic>\n                    ,\n                    <jats:italic>VCAN<\/jats:italic>\n                    , and\n                    <jats:italic>NRG1<\/jats:italic>\n                    , among other genes, that was significantly enriched in the TZ. Analysis of previously published scRNA\u2010seq datasets further confirmed that\n                    <jats:italic>WIF1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    basal cells were significantly enriched in BPH compared with normal prostate. Pathway and cell\u2013cell communication analyses revealed that this basal subtype is associated with programs related to cell proliferation, epithelial\u2013mesenchymal transition, immune regulation, angiogenesis, and hormone response. Together, the molecular signature, zonal distribution, and pathway enrichment suggest that TZ\u2010enriched\n                    <jats:italic>WIF1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    basal cells may contribute to BPH pathogenesis by promoting epithelial and stromal remodeling. \u00a9 2026 The Author(s).\n                    <jats:italic>The Journal of Pathology<\/jats:italic>\n                    published by John Wiley &amp; Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.\n                  <\/jats:p>","DOI":"10.1002\/path.70117","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:00:26Z","timestamp":1789030826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A transition zone enriched\n                    <scp>\n                      <i>WIF1<\/i>\n                    <\/scp>\n                    <sup>+<\/sup>\n                    basal cell subtype is associated with benign prostatic hyperplasia"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-1058","authenticated-orcid":false,"given":"Rulin","family":"Wang","sequence":"first","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University, School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University, School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-0373","authenticated-orcid":false,"given":"Mindy K","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University, Feinberg School of Medicine  Chicago IL 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