{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:46:00Z","timestamp":1761162360961,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,8,29]],"date-time":"2001-08-29T00:00:00Z","timestamp":999043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peripheral T\u2010cell lymphomas (PTCL) are usually characterized by aggressive clinical behaviour and poor clinical outcome, but their biological background has not been extensively investigated to date, due to their low incidence, about 10% of all non\u2010Hodgkin's lymphoma cases in Western countries, and also to the paucity of specific molecular\u2010genetic abnormalities. Neverthless, there is increasing biological and clinical evidence that primary nodal PTCL should be considered separately from extra\u2010nodal cases, but little is known about biological factors of possible clinical and prognostic impact. This immunohistochemical study has analysed the expression of p53, Mdm2, p21\n                    <jats:sup>WAF1<\/jats:sup>\n                    , BCL\u20102 and p\u2010glycoprotein (MDR\u20101 gene product) in a series of 45 cases of nodal peripheral T\u2010cell lymphomas (PTCL) with \u2018high\u2010grade\u2019 histology. The immunohistochemical findings were then correlated with proliferative activity and clinical outcome. p53 was over\u2010expressed in 13 cases (28.9%). p53 positive cases showed significantly higher proliferative activity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.01), more frequent expression of Bcl\u20102 (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.01) and less frequent expression of p21\n                    <jats:sup>WAF1<\/jats:sup>\n                    than p53 negative cases. Mdm2 and p\u2010glycoprotein were expressed in 4\/13 (30.8%) and 8\/13 (61.5%) p53 positive cases respectively, and in none (0%) of the p53 negative cases (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.01). Analysis of the survival curves showed that p53 positive cases were associated with a significantly poorer clinical outcome than p53 negative cases, in terms of both overall survival (\n                    <jats:italic>p<\/jats:italic>\n                    =0.0032) and event\u2010free survival (\n                    <jats:italic>p<\/jats:italic>\n                    =0.0004). Furthermore, multivariate analysis showed that p53 expression was the most important independent prognostic variable. These findings indicate that p53 over\u2010expression identifies a subset of nodal PTCL cases with a distinctive biological profile (higher proliferative activity, less frequent expression of p21\n                    <jats:sup>WAF1<\/jats:sup>\n                    and more frequent expression of Bcl\u20102, Mdm2 and p\u2010glycoprotein than p53 negative cases) and poor clinical outcome. The immunohistochemical analysis of p53 expression is a simple, rapid and low\u2010cost method which may provide information of potential clinical and prognostic value in nodal peripheral T\u2010cell lymphomas. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.945","type":"journal-article","created":{"date-parts":[[2005,1,23]],"date-time":"2005-01-23T20:49:37Z","timestamp":1106513377000},"page":"361-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["p53 over\u2010expression identifies a subset of nodal peripheral T\u2010cell lymphomas with a distinctive biological profile and poor clinical outcome"],"prefix":"10.1002","volume":"195","author":[{"given":"Edoardo","family":"Pescarmona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pignoloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Puopolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Addesso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo D.","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008414002612"},{"key":"e_1_2_6_5_2","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. 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