{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T05:55:22Z","timestamp":1700200522305},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,5,8]],"date-time":"2003-05-08T00:00:00Z","timestamp":1052352000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aufgrund klinischer Daten ist die Gabe von Johanniskrautextrakten bei Patienten abzulehnen, die Arzneimittel mit geringer therapeutischer Breite einnehmen m\u00fcssen (z. B. die Immunsuppressiva Ciclosporin und Tacrolimus, Antikoagulantien vom Coumarin\u2010Typ, Virustatika wie HIV\u2010Proteaseinhibitoren und Nichtkompetitive\u2010Reverse\u2010Transkriptase\u2010Inhibitoren sowie Chemotherapeutika wie Irinotecan). Eine Interaktion mit oralen Kontrazeptiva erscheint m\u00f6glich. Die pharmakokinetischen Interaktionen nach wiederholter Gabe von Johanniskrautextrakten beruhen auf einer Erh\u00f6hung der Aktivit\u00e4t fremdstoffmetabolisierender Enzyme (CYP3A4) und von Transportproteinen (MDR1\u2010Produkt P\u2010Glycoprotein). Eine Kombination mit weiteren Antidepressiva sollte aufgrund des m\u00f6glichen Auftretens eines Serotonin\u2010Syndroms unterbleiben. Zudem k\u00f6nnen bestimmte therapeutische Situationen, wie beispielsweise eine Lasertherapie, das Risiko phototoxischer Reaktionen erh\u00f6hen. Unter Beachtung dieser Risiken ist die Gabe von Johanniskrautextrakt jedoch eine sichere und wirkungsvolle Alternative zur Behandlung leichter bis mittelstarker depressiver Episoden.<\/jats:p>","DOI":"10.1002\/pauz.200390072","type":"journal-article","created":{"date-parts":[[2003,5,9]],"date-time":"2003-05-09T15:03:04Z","timestamp":1052492584000},"page":"242-246","source":"Crossref","is-referenced-by-count":2,"title":["Woran sollte man denken bei der Gabe von Johanniskrautpr\u00e4paraten?: Unerw\u00fcnschte Arzneimittelwirkungen und \u2010interaktionen"],"prefix":"10.1002","volume":"32","author":[{"given":"Andreas","family":"Johne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivar","family":"Roots","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"152","article-title":"Incidence and clinical relevance of the interactions and side effects of Hypericum preparations.","volume":"8","author":"Schulz V.","year":"2001","journal-title":"Phytomedicine"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-001-0317-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979527"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/089198879901200103"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"Johne A. Mai I. Bauer S. Kr\u00fcger H. Arold G. St\u00f6rmer E. Gerloff T. und Roots I.: \u00dcbersicht zu Interaktionsstudien mit Johanniskraut\u2010Extrakten (2001). In: V. Schulz N. Rietbrock I. Roots D. Loew (Ed.): Phytopharmaka VII Forschung und klinische Anwendung Steinkopff Verlag Darmstadt 149\u2010161.","DOI":"10.1007\/978-3-642-57528-0_15"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/cp.1999.v66.a101944"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01683.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200202000-00008"}],"container-title":["Pharmazie in unserer Zeit"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.200390072","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pauz.200390072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T05:06:06Z","timestamp":1700197566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pauz.200390072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1002\/pauz.200390072"],"URL":"https:\/\/doi.org\/10.1002\/pauz.200390072","archive":["Portico"],"relation":{},"ISSN":["0048-3664","1615-1003"],"issn-type":[{"value":"0048-3664","type":"print"},{"value":"1615-1003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}