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Historisch gesehen sind sie ein Paradebeispiel f\u00fcr die erfolgreiche Entwicklung hochwirksamer Arzneistoffe \u2013 ausgehend von Leitstrukturen, deren diuretische Wirkung zuf\u00e4llig entdeckt worden war. Nach Jahrzehnten der Stagnation auf diesem Gebiet werden zur Zeit neue Diuretika mit verbesserten Eigenschaften und teilweise neuartigen Wirkungsmechanismen entwickelt.<\/jats:p>","DOI":"10.1002\/pauz.200600178","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T14:10:31Z","timestamp":1150899031000},"page":"310-320","source":"Crossref","is-referenced-by-count":0,"title":["Medizinische Chemie der Diuretika: Entwicklung einer erfolgreichen Wirkstoffgruppe"],"prefix":"10.1002","volume":"35","author":[{"given":"Andreas","family":"Brunschweiger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","unstructured":"Fink C.A. 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