{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:12:13Z","timestamp":1760548333721},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Das antibakterielle Spektrum und die Aktivit\u00e4t der Antibiotika werden von einer Reihe von physikochemischen Eigenschaften bestimmt. Aktivit\u00e4t gegen Gram\u2010positive Erreger wird durch Lipophilie erreicht, w\u00e4hrend ein h\u00f6heres Ma\u00df an Hydrophilie f\u00fcr die Penetration durch die wassergef\u00fcllten Poren der Gram\u2010negativen Bakterien notwendig ist. Aktivit\u00e4t gegen Pseudomonaden h\u00e4ngt besonders von dem Vorhandensein einer positiven Ladung ab, die permanent oder auch pH\u2010abh\u00e4ngig vorhanden sein kann. So haben fast alle Carbapeneme positiv geladene oder ladbare Stickstoffatome und sind deshalb gegen <jats:italic>Pseudomonas aeruginosa<\/jats:italic> und Enterobacteriaceae wirksam. Lipophile Carbapeneme (z.B. L\u2010786.392) sind folgerichtig gegen Gram\u2010positive Erreger wie Staphylokokken und Enterokokken wirksam. So l\u00e4sst sich leicht verstehen, dass das lipophile Penem Faropenem nicht gegen Pseudomonaden wirksam ist: Es ist nicht positiv geladen und kann deshalb nicht durch die hydrophilen Poren penetrieren. Mit diesen einfachen Regeln kann fast immer das Wirkspektrum der <jats:italic>\u03b2<\/jats:italic>\u2010Lactam\u2010Antibiotika erkl\u00e4rt werden.<\/jats:p>","DOI":"10.1002\/pauz.200600186","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T11:29:28Z","timestamp":1156505368000},"page":"410-414","source":"Crossref","is-referenced-by-count":6,"title":["Von Penicillin G zu tricyclischen \u03b2\u2010Lactamen: Struktur\u2010Wirkungs\u2010Beziehungen"],"prefix":"10.1002","volume":"35","author":[{"given":"Ulrike","family":"Holzgrabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2005.030.01.873914"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.11.012"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071141"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.12.003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.550-555.2002"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.06.014"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600790816"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2327-2332.2002"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2228-2232.2004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh205"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh209"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00008-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01271.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.819-821.2006"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6017(200002)89:2<232::AID-JPS10>3.0.CO;2-5"}],"container-title":["Pharmazie in unserer Zeit"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.200600186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pauz.200600186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T17:49:51Z","timestamp":1700070591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pauz.200600186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,25]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/pauz.200600186"],"URL":"https:\/\/doi.org\/10.1002\/pauz.200600186","archive":["Portico"],"relation":{},"ISSN":["0048-3664","1615-1003"],"issn-type":[{"value":"0048-3664","type":"print"},{"value":"1615-1003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,25]]}}}