{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:10:22Z","timestamp":1700071822814},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CA\u2010MRSA sind weltweit ein <jats:italic>emerging pathogen<\/jats:italic> au\u00dferhalb von medizinischen Einrichtungen. Sie betreffen Patienten ohne Risikofaktoren, insbesondere auch Kinder und Erwachsene im j\u00fcngeren Alter. Typischerweise kommt es zu Haut\u2010 und Weichteilinfektionen, die h\u00e4ufig mit Komplikationen verlaufen (multipel, rezidivierend, seltener Endokarditis, Osteomyelitis, septische Arthritis). Seltene schwere Komplikationen sind nekrotisierende Pneumonien, nekrotisierende Fasziitis, Purpura fulminans und Waterhouse\u2010Friderichsen\u2010Syndrom. Als besonderen Virulenzfaktor weisen CA\u2010MRSA u.a. das Panton\u2010Valentine\u2010Leukozidin auf. Die St\u00e4mme sind resistent gegen alle <jats:italic>\u03b2<\/jats:italic>\u2010Lactam\u2010Antibiotika. Zur Therapie sind Clindamycin, Doxycyclin, Moxifloxacin, Co\u2010Trimoxazol, Linezolid, Glykopeptide und Daptomycin geeignet. Die Sanierung des Tr\u00e4gerstatus ist aufw\u00e4ndig und verlangt eine sorgf\u00e4ltige Planung. Um eine weitere Verbreitung zu verhindern, sind verbesserte diagnostische, therapeutische und hygienische Ma\u00dfnahmen bei niedergelassenen \u00c4rzten und in Krankenh\u00e4usern n\u00f6tig.<\/jats:p>","DOI":"10.1002\/pauz.200600188","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T11:30:14Z","timestamp":1156505414000},"page":"422-425","source":"Crossref","is-referenced-by-count":0,"title":["Methicillin\u2010resistenter <i>Staphylococcus aureus<\/i>: \u03b2\u2010Lactam\u2010Resistenz \u201ctrifft\u201d Virulenz"],"prefix":"10.1002","volume":"35","author":[{"given":"Hans\u2010J\u00f6rg","family":"Linde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Lehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-865066"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/345436"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4289-4294.2002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1341-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08713-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/313461"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74814-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000133044.79130.2a"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.546-555.2004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2732"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/380909"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.12.1520"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-0975-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-0008-8"}],"container-title":["Pharmazie in unserer Zeit"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.200600188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pauz.200600188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T17:49:35Z","timestamp":1700070575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pauz.200600188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,25]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/pauz.200600188"],"URL":"https:\/\/doi.org\/10.1002\/pauz.200600188","archive":["Portico"],"relation":{},"ISSN":["0048-3664","1615-1003"],"issn-type":[{"value":"0048-3664","type":"print"},{"value":"1615-1003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,25]]}}}