{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T21:10:19Z","timestamp":1699996219164},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T00:00:00Z","timestamp":1197590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Manche Infektionen bekommt man bekanntlich nur einmal \u2013 sie verleihen eine lebenslange Immunit\u00e4t. Das ist die Ursache f\u00fcr klassische \u201cKinderkrankheiten\u201d, die sich nat\u00fcrlicherweise innerhalb der am wenigsten immunisierten Bev\u00f6lkerungsgruppe, eben der Kinder, ausbreiten, w\u00e4hrend die meisten Erwachsenen durch fr\u00fcher durchgemachte Infektionen vor einem erneuten Ausbruch der Krankheit gesch\u00fctzt sind. Diesen Mechanismus kann man sich zunutze machen, indem man Gesunde absichtlich mit schwachen Krankheitserregern in Kontakt bringt, die aber noch in der Lage sind, Immunit\u00e4t zu erzeugen. Das ist das Prinzip der aktiven Immunisierung. Historisch interessant ist, dass dies bereits zu Zeiten gelang, als man nur vage Vorstellungen von einem \u201cContagium\u201d hatte und von der Existenz pathogener Mikroorganismen noch nichts ahnte.<\/jats:p>","DOI":"10.1002\/pauz.200700247","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T22:17:51Z","timestamp":1197670671000},"page":"12-18","source":"Crossref","is-referenced-by-count":1,"title":["Zur Geschichte der aktiven Immunisierung. Vorbeugen ist besser als Heilen"],"prefix":"10.1002","volume":"37","author":[{"given":"Axel","family":"Helmst\u00e4dter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,14]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Henig E.\u2010M.: 200 Jahre Pockenimpfstoff in Deutschland. Quellen und Studien zur Geschichte der Pharmazie Bd. 73. Wiss. Verl.\u2010Ges. 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