{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:07:15Z","timestamp":1700006835522},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T00:00:00Z","timestamp":1225065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obwohl Husten einer der h\u00e4ufigsten Beschwerden ist, verf\u00fcgen wir nicht \u00fcber effektive und nebenwirkungsarme Medikamente zur Therapie. Falls eine kausale Therapie (z.B. Operation des Bronchialkarzinoms) nicht m\u00f6glich ist, oder die eingeleitete kausale Therapie nur langsam wirkt (z.B. die Tuberkulosetherapie) ben\u00f6tigen wir symptomatisch wirkende Medikamente zur Linderung. Es haben sich zwei therapeutische Ans\u00e4tze eingeb\u00fcrgert: die antitussive Therapie f\u00fcr den nicht produktiven Reizhusten und die protussive Therapie mit Expektorantien zur Linderung des produktiven Hustens. Chemisch definierte Antitussiva werden aus Alkaloiden des Schlafmohns abgeleitet und haben mehr oder weniger ausgepr\u00e4gt die Nebenwirkungen der Morphinderivate, die Addiktionsgefahr sollte keinesfalls untersch\u00e4tzt werden. Ein objektiver Wirksamkeitsnachweis f\u00fcr die besonders in Deutschland beliebten Expektorantien fehlt, subjektiv werden sie jedoch h\u00e4ufig als hilfreich empfunden.<\/jats:p>","DOI":"10.1002\/pauz.200800286","type":"journal-article","created":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T06:50:29Z","timestamp":1225090229000},"page":"472-476","source":"Crossref","is-referenced-by-count":0,"title":["Stellenwert chemisch\u2010synthetischer Antitussiva und Expektorantien. Waisenkinder der pharmakologischen Forschung?"],"prefix":"10.1002","volume":"37","author":[{"given":"Peter","family":"Kardos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2178"},{"key":"e_1_2_1_3_2","first-page":"437","article-title":"Chronisch persistierender Husten (CPH) in der Praxis: Diagnostik und Therapie bei 329 Patienten in 2 Jahren.","volume":"50","author":"Kardos P.","year":"1996","journal-title":"Pneumologie"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/pulp.1996.0038"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0012-3692(15)51851-5","article-title":"Cough in COPD: Correlation of Objective Monitoring With Cough Challenge and Subjective Assessments.","volume":"130","author":"Smith J.","year":"2006","journal-title":"Chest"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-892OC"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9033-y"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66456-2"},{"key":"e_1_2_1_9_2","unstructured":"Association of the European Self\u2010Medication Industry. www.AESGP.be\/encour\/frame.html (letzter Zugriff 18.7.2008)."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/pupt.2002.0364"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90506-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042976"}],"container-title":["Pharmazie in unserer Zeit"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.200800286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pauz.200800286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:36:04Z","timestamp":1699972564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pauz.200800286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,27]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1002\/pauz.200800286"],"URL":"https:\/\/doi.org\/10.1002\/pauz.200800286","archive":["Portico"],"relation":{},"ISSN":["0048-3664","1615-1003"],"issn-type":[{"value":"0048-3664","type":"print"},{"value":"1615-1003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,27]]}}}