{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T05:02:39Z","timestamp":1700024559531},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,4,25]],"date-time":"2009-04-25T00:00:00Z","timestamp":1240617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnesium ist nach dem Kalium das mengenm\u00e4\u00dfig zweith\u00e4ufigste intrazellul\u00e4re mineralische Element in unserem K\u00f6rper. Aufgrund seiner vielf\u00e4ltigen Funktionen im K\u00f6rper f\u00fchrt eine unzureichende Versorgung an Magnesium zu einem breiten Spektrum an Mangelsymptomen. Der Magnesium\u2010Haushalt des K\u00f6rpers wird durch Resorption aus dem Darm, Ausscheidung \u00fcber den Stuhl und den Urin sowie Einlagerung oder Freisetzung in das bzw. aus dem Skelett reguliert. Die Resorption von Magnesium erfolgt \u00fcber den kompletten Darm durch zwei verschiedene Prozesse, zum einen Carrier\u2010vermittelt, zum anderen parazellul\u00e4r durch passive Diffusion. Die Resorptionsrate aus der Nahrung liegt normalerweise bei 35 bis 55 %. Bei fettreicher Nahrung oder der Aufnahme verschiedener Nahrungsinhaltsstoffe, die die Magnesium\u2010Resorption hemmen wie Phosphat, Phytat oder Oxalat, kann sie aber deutlich reduziert sein. F\u00fcr die Wirksamkeit von Magnesium\u2010Pr\u00e4paraten spielt die intestinale Bioverf\u00fcgbarkeit des Magnesiums eine entscheidende Rolle. Organische Magnesium\u2010Verbindungen wie das Citrat, Aspartat, Aspartat\u2010hydrochlorid, Gluconat oder Aminos\u00e4urekomplexe haben eine deutlich h\u00f6here Bioverf\u00fcgbarkeit als anorganische Magnesium\u2010Salze wie das Carbonat, Oxid oder Sulfat (mit Ausnahme von Chlorid). Organische Magnesium\u2010Verbindungen sind als Supplemente daher den weniger gut resorbierbaren anorganischen Verbindungen wie Magnesiumoxid oder \u2010carbonat vorzuziehen.<\/jats:p>","DOI":"10.1002\/pauz.200800316","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T23:01:00Z","timestamp":1240873260000},"page":"262-267","source":"Crossref","is-referenced-by-count":1,"title":["Magnesium\u2010Verbindungen. Aufnahme, Funktionen und therapeutische Aspekte"],"prefix":"10.1002","volume":"38","author":[{"given":"Klaus","family":"Eder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,25]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Shils M.E.: Magnesium. In: Handbook of Nutritionally Essential Mineral Elements. O'Dell B.L. Sunde R.A. (eds.) Marcel Dekker; New York (1997)."},{"key":"e_1_2_1_3_2","unstructured":"Biesalski H.K. et al.: Ern\u00e4hrungsmedizin Georg Thieme\u2010Verlag; Stuttgart (1999)."},{"key":"e_1_2_1_4_2","unstructured":"Classen H.G.: Magnesium. In: Vitamine Spurenelemente und Mineralstoffe. Bisalski H.K. K\u00f6hrle J. Sch\u00fcmann K. (eds.). Georg\u2010Thieme Verlag Stuttgart (2002) pp. 137\u2013137."},{"key":"e_1_2_1_5_2","unstructured":"Suter P.M.: Checkliste Ern\u00e4hrung. 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