{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:11:45Z","timestamp":1700568705603},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infektionen mit Flaviviren, beispielsweise dem West\u2010Nil\u2010 und dem Dengue\u2010Virus, stellen ein zunehmendes medizinisches Problem in den Tropen und Subtropen dar. F\u00fcr die Zukunft kann, bedingt durch eine Ausbreitung der \u00dcbertr\u00e4gerinsekten in gem\u00e4\u00dfigte Breiten, ein endemisches Auftreten auch in Mitteleuropa nicht ausgeschlossen werden. Die Bek\u00e4mpfung von Flaviviren erfolgt momentan insbesondere durch die Kontrolle der \u00dcbertr\u00e4gerinsekten. Die Entwicklung von Impfstoffen und antiviralen Arzneimitteln wird intensiv betrieben, mit der Zulassung entsprechender Pr\u00e4parate ist jedoch erst in einigen Jahren zu rechnen.<\/jats:p>","DOI":"10.1002\/pauz.201000352","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T19:59:17Z","timestamp":1261598357000},"page":"50-53","source":"Crossref","is-referenced-by-count":1,"title":["Dengue\u2010 und West\u2010Nil\u2010Virus. Antivirale Strategien"],"prefix":"10.1002","volume":"39","author":[{"given":"Christian","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04576-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03538-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.480"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3684.638"},{"key":"e_1_2_1_6_2","first-page":"1","article-title":"First record of Stegomyia albopicta (Skuse) (Diptera: Culicidae) in Germany.","volume":"26","author":"Pluskota B.","year":"2008","journal-title":"Eur. Mosquito Bullet."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.04.001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2008.0049"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0801.010252"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710005383X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1128\/AAC.00189-09","article-title":"Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein. Antimicrob.","volume":"58","author":"Qing M.","year":"2009","journal-title":"Agents Chemother."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22835"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4980-4988.2005"}],"container-title":["Pharmazie in unserer Zeit"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.201000352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.201000352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pauz.201000352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:42:49Z","timestamp":1700566969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pauz.201000352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,23]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/pauz.201000352"],"URL":"https:\/\/doi.org\/10.1002\/pauz.201000352","archive":["Portico"],"relation":{},"ISSN":["0048-3664","1615-1003"],"issn-type":[{"value":"0048-3664","type":"print"},{"value":"1615-1003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,23]]}}}