{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T16:10:35Z","timestamp":1700496635154},"reference-count":4,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T00:00:00Z","timestamp":1319500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie in unserer Zeit"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insgesamt kennt man acht Nematodenarten, die eine Filariose, eine Wurmkrankheit des Menschen, verursachen k\u00f6nnen. Zwei sind f\u00fcr die lymphatische Filariasis verantwortlich: Wucheria bancrofti steht f\u00fcr 90 Prozent der gesch\u00e4tzten 120 Millionen F\u00e4lle in 83 L\u00e4ndern und Brugia malayi (zumeist in S\u00fcdostasien) f\u00fcr die restlichen 10 Prozent (siehe Abb. 1). Insgesamt sind 1,3 Milliarden Menschen einem Infektionsrisiko ausgesetzt. Zudem gibt es noch Onchocerca volvulus, die bei ca. 37 Millionen Menschen in 34 L\u00e4ndern (h\u00e4ufig Afrika) die Flussblindheit hervorruft, die bedeutendste Filariose.<\/jats:p>","DOI":"10.1002\/pauz.201190071","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T11:29:50Z","timestamp":1319542190000},"page":"450-451","source":"Crossref","is-referenced-by-count":0,"title":["Die Natur als Apotheke gegen Tropenkrankheiten: Tirandamycin B gegen lymphatische Filariosen"],"prefix":"10.1002","volume":"40","author":[{"given":"Ulrike","family":"Holzgrabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,25]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"http:\/\/translate.google.de\/translate?hl=de&langpair=en%7Cde&u=http:\/\/www.who.int\/mediacentre\/factsheets\/fs102\/en\/ (abgefragt 21.6.2011)."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60586-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.11.049"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol200420u"}],"container-title":["Pharmazie in unserer Zeit"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpauz.201190071","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pauz.201190071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T15:47:29Z","timestamp":1700495249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pauz.201190071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,25]]},"references-count":4,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/pauz.201190071"],"URL":"https:\/\/doi.org\/10.1002\/pauz.201190071","archive":["Portico"],"relation":{},"ISSN":["0048-3664","1615-1003"],"issn-type":[{"value":"0048-3664","type":"print"},{"value":"1615-1003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,25]]}}}